New air-stable catalysts for general and efficient Suzuki-Miyaura cross-coupling reactions of heteroaryl chlorides
New air-stable catalysts for general and efficient Suzuki-Miyaura cross-coupling reactions of heteroaryl chlorides
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DOI：
10.1021/ol060268g
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发表时间：
2006-04-27
期刊：
影响因子：
5.2
通讯作者：
Reider, PJ
中科院分区：
文献类型：
--
作者：
Guram, AS;King, AO;Reider, PJ
新的空气稳定的PdCl_2 {（PBu_2）-Bu-1（p-R-Ph）}（2）（R = H，NMe_2，CF_3）配合物代表了芳基卤化物（包括五元杂芳基卤化物和杂原子取代的六元杂芳基氯化物）与各种芳基硼酸的Suzuki-Miyaura交叉偶联反应的简单、通用和有效的催化剂。观察到高的产物产率（89-99%的分离产率）和周转数（10000 TON）。
New air-stable PdCl2{(PBu2)-Bu-1(p-R-Ph)}(2) (R = H, NMe2, CF3,) complexes represent simple, general, and efficient catalysts for the Suzuki-Miyaura cross-coupling reactions of aryl halides including five-membered heteroaryl halides and heteroatom-substituted six-membered heteroaryl chlorides with a diverse range of arylboronic acids. High product yields (89-99% isolated yields) and turn-over-numbers (10000 TON) are observed.