Exposure to ambient air pollution and indicators of maternal liver function during pregnancy: Findings from a birth cohort study in Foshan City, Southern China
Exposure to ambient air pollution and indicators of maternal liver function during pregnancy: Findings from a birth cohort study in Foshan City, Southern China
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DOI：
10.1016/j.atmosenv.2022.119408
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发表时间：
2022-10-05
影响因子：
5
通讯作者：
Lin，Hualiang
中科院分区：
文献类型：
--
作者：
Yang，Yin;Lin，Qingmei;Lin，Hualiang
有关妊娠期空气污染暴露与母亲肝功能之间关系的证据很少。我们通过分析在中国南方佛山市进行的一项出生队列研究的数据来探讨这一主题。2015年至2019年，我们从佛山市16家医院共招募了49568名孕妇。从医院病历中收集基本的社会人口信息和生活方式因素。采用反距离加权法评估研究期间每个参与者的每日PM2.5、PM10、SO2、NO2和o3暴露量。然后，我们给每个参与者分配了妊娠1、妊娠2和妊娠前两个月的平均空气污染物水平。每个参与者的肝功能指标（肝酶、血清蛋白和血清胆红素）在孕晚期产前访问时进行测量。使用混合效应线性和逻辑回归模型来评估妊娠期空气污染暴露与母亲肝功能指标的关系。我们的研究结果表明，母亲在怀孕期间暴露于空气污染中，特别是在妊娠中期，与肝酶水平升高和血清蛋白水平降低有关。
Evidence concerning the associations between gestational air pollution exposure and maternal liver function is scarce. We explored this topic by analyzing data from a birth cohort study conducted in Foshan city, Southern China. Between 2015 and 2019, we recruited a total of 49,568 pregnant women from 16 hospitals in Foshan city. Basic socio-demographical information and lifestyle factors was collected from the hospital medical records. Daily PM2.5, PM10, SO2, NO2, and O3exposure of each participant during study period was assessed by inverse-distance weighted method. Then, we assigned the average air pollutant levels during trimester 1, trimester 2, and the first two trimesters to each participant. Liver function indicators (liver enzymes, serum protein, and serum bilirubin) of each participant were measured during their third trimester prenatal visit. Mixed-effects linear and logistic regression models were used to evaluate the associations of gestational air pollution exposure and maternal liver function indicators. Our findings suggested that maternal exposure to air pollution during pregnancy, especially trimester 2, was associated with increased liver enzyme levels and decreased serum protein levels.