Harnessing Oxidative Microenvironment forIn VivoSynthesis ofSubcellular Conductive Polymer Microesicles Enhances Nerve Reconstruction
Harnessing Oxidative Microenvironment forIn VivoSynthesis ofSubcellular Conductive Polymer Microesicles Enhances Nerve Reconstruction
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DOI：
10.1021/acs.nanolett.2c01123
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发表时间：
2022-05-11
期刊：
影响因子：
10.8
通讯作者：
Zhu, Chuhong
中科院分区：
文献类型：
--
作者：
Qin, Yinhua;Fan, Yonghong;Zhu, Chuhong
导电聚合物是一种很有前途的生物材料，可以解决生物界面上的信号连接问题，促进组织再生。然而，在亚细胞尺度上调节材料的微观结构以提供导电基底和细胞之间更无缝的界面仍然是一个巨大的挑战。在这里，我们证明了化学因素和酶携带的亚细胞结构在病变部位提供了一个天然的生物反应器，自组装导电微泡（CMV），以改善生物电信号重建。在损伤神经的早期，合成的CMV参与了神经的电传导。此外，CMV最终通过毛细淋巴管排出，以减少占位和慢性炎症。因此，我们提供了一个原型，结合特定的生理微环境和高分子化学，在体内制造具有自适应界面的亚细胞功能材料，用于生物医学应用
Conductive polymers (CPs) are promising bio-materials to address signal connection at biointerfaces for tissueregeneration. However, regulating material microstructure at thesubcellular scale to provide a more seamless interface betweenconductive substrates and cells remains a great challenge. Here, wedemonstrate that chemical factors and enzyme-carried subcellularstructures at lesion site provide a natural bioreactor to self-assemble conductive microvesicles (CMVs) for improvingbioelectrical signal reconstruction. The synthesized CMVscontribute to the electrical conduction of the injured nerve inthe early stage. Moreover, CMVs are eventually expelled vialymphatic capillary to minimize space-occupying and chronicinflammation. Therefore, we provide a prototype to integratespecific physiological microenvironments and polymer chemistry to manufacture subcellular functional materials with self-adaptiveinterfacein vivofor biomedical applications