Chromatin and Epigenetic Rearrangements in Embryonic Stem Cell Fate Transitions.
Chromatin and Epigenetic Rearrangements in Embryonic Stem Cell Fate Transitions.
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DOI：
10.3389/fcell.2021.637309
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发表时间：
2021
影响因子：
5.5
通讯作者：
Hutchins AP
中科院分区：
文献类型：
--
作者：
Sun L;Fu X;Ma G;Hutchins AP
A major event in embryonic development is the rearrangement of epigenetic information as the somatic genome is reprogrammed for a new round of organismal development. Epigenetic data are held in chemical modifications on DNA and histones, and there are dramatic and dynamic changes in these marks during embryogenesis. However, the mechanisms behind this intricate process and how it is regulating and responding to embryonic development remain unclear. As embryos develop from totipotency to pluripotency, they pass through several distinct stages that can be captured permanently or transiently in vitro. Pluripotent naïve cells resemble the early epiblast, primed cells resemble the late epiblast, and blastomere-like cells have been isolated, although fully totipotent cells remain elusive. Experiments using these in vitro model systems have led to insights into chromatin changes in embryonic development, which has informed exploration of pre-implantation embryos. Intriguingly, human and mouse cells rely on different signaling and epigenetic pathways, and it remains a mystery why this variation exists. In this review, we will summarize the chromatin rearrangements in early embryonic development, drawing from genomic data from in vitro cell lines, and human and mouse embryos.
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影响因子：
21.3
作者：
Boroviak T;Loos R;Bertone P;Smith A;Nichols J
通讯作者：
Nichols J
影响因子：
13.6
作者：
Cao K;Collings CK;Morgan MA;Marshall SA;Rendleman EJ;Ozark PA;Smith ER;Shilatifard A
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Shilatifard A
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2.7
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BACHVAROVA, R
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Vallier, Ludovic
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作者：
Carter, M. G.;Smagghe, B. J.;Bamdad, Cynthia C.
通讯作者：
Bamdad, Cynthia C.