Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1‐q32
Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1‐q32
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精神分裂症与染色体 13q14.1-q32 上的标记连锁的提示性证据
作者：
M. Lin;D. Curtis;N. Williams;M. Arranz;S. Nanko;D. Collier;P. McGuffin;R. Murray;M. Owen;M. Gill;J. Powell
家庭、双胞胎和收养研究强调了基因在精神分裂症病因学中的影响，尽管遗传模式尚不清楚。我们利用一系列多病家系对精神分裂症的主效基因进行了系统的研究，并报告了与13号染色体上的标记在异质性下连锁的初步结果。标记D13S144在0=0时的LOT2得分为1.61，α为0.5时，附近的标记也产生了正值。
Family, twin and adoption studies highlight the influence of genes in the aetiology of schizophrenia, though the mode of inheritance is unclear. We have been conducting a systematic search for major genes in schizophrenia using a series of multiply affected families and report preliminary results of linkage under heterogeneity with markers on chromosome 13. A lod2 score of 1.61 for marker D13S144 was obtained at 0 = 0 and α of 0.5 and nearby markers also produced positive values.