Development of the Carboxamide Protecting Group, 4-(tert-Butyldimethylsiloxy)-2-methoxybenzyl
Development of the Carboxamide Protecting Group, 4-(tert-Butyldimethylsiloxy)-2-methoxybenzyl
复制标题
甲酰胺保护基团 4-(叔丁基二甲基硅氧基)-2-甲氧基苄基的开发
作者：
Muranaka;Kazuhiro; Ichikawa;Satoshi; and Matsuda;Akira
合成了新的羧胺保护基团4-(叔丁基二甲基硅氧基)-2-甲氧基苄基(SiMB)。虽然可以使用温和的碱性脱硅方法去除这种SiMB基团，但也可以在强酸性或氧化条件下解除保护。还展示了该基团在简单的羧胺基团以及含有环状支架的更复杂和更酸敏感的腺苷衍生物中的应用。
The new carboxamide protecting group, 4-(tert-butyldimethylsiloxy)-2-methoxybenzyl (SiMB), has been developed. While this SiMB group can be removed using mild basic desilylation methods, it can also be deprotected under strongly acidic or oxidative conditions. An application of this group to simple carboxamide groups, as well as to more complex and acid-sensitive adenosine derivatives containing a cyclophane scaffold, was also demonstrated.