The naloxone test for opiate dependence
The naloxone test for opiate dependence
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纳洛酮测试阿片依赖
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
A. Goldstein
中科院分区：
文献类型：
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作者：
B. Judson;D. Himmelberger;A. Goldstein
Naloxone tests for opiate dependence were given to 296 applicants for treatment with the surrogate opiate levomethadyl acetate (LAAM, levo‐alpha‐acetylmethadol) and to 103 applicants for treatment with the opiate antagonist naltrexone. Thirty‐five of the 296 LAAM applicants applied first for LAAM, then following detoxification, for naltrexone. There was a dramatic decrease in withdrawal signs and symptoms when the subject went from an opiate‐dependent to a nondependent state. From our experience, we devised a scoring guide and testing procedure based on objective signs. We propose a 2‐step test, with an initial intramuscular dose, then (if necessary) an intravenous dose, to determine an applicant's eligibility for surrogate opiate or narcotic antagonist treatment.
