Systemic and regional free fatty acid metabolism in type 2 diabetes
Systemic and regional free fatty acid metabolism in type 2 diabetes
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DOI：
10.1152/ajpendo.2001.280.6.e1000
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发表时间：
2001-06-01
影响因子：
5.1
通讯作者：
Jensen, MD
中科院分区：
文献类型：
--
作者：
Basu, A;Basu, R;Jensen, MD
为了确定2型糖尿病是否改变了全身和局部游离脂肪酸（[H-3]棕榈酸酯）代谢，14名非糖尿病（ND）和14名2型糖尿病（D）受试者接受了高胰岛素-高血糖（类似于9.3 mM）钳夹。受试者的年龄、体重指数、体脂百分比和去脂体重相匹配。D组内脏脂肪含量显著高于ND组（P < 0.05）。在生长抑素、替代生长激素和胰高血糖素输注期间，输注胰岛素以达到中等（75 pmol/l）和高（类似于150 pmol/l）生理胰岛素水平。在两个胰岛素输注间隔期间，D受试者的全身和局部（内脏和腿部）棕榈酸释放量均大于ND受试者（P < 0.02）。内脏、腿部和非内脏上身区域对全身棕榈酸释放的相对贡献在各组之间没有差异，尽管最后一个区域对全身棕榈酸释放的贡献最大（75%）。在两种胰岛素输注期间，内脏脂肪面积与全身棕榈酸流量相关（r = 0.45，P < 0.03）。我们的结论是，2型糖尿病与胰岛素抑制脂肪分解的普遍损害相比，同样肥胖的ND个人。
To determine whether type 2 diabetes mellitus alters systemic and regional free fatty acid ([H-3]palmitate) metabolism, 14 nondiabetic (ND) and 14 type 2 diabetic (D) subjects underwent hyperinsulinemic-hyperglycemic (similar to9.3 mM) clamps. The subjects were matched for age, body mass index, percent body fat, and fat-free mass. D subjects had more (P < 0.05) visceral fat than ND. During somatostatin, replacement growth hormone, and glucagon infusions, insulin was infused to achieve moderate (75 pmol/l) and high (similar to 150 pmol/l) physiological insulin levels. D subjects had greater (P < 0.02) systemic and regional (splanchnic and leg) palmitate release than ND subjects during both insulin infusion intervals. The relative contributions of splanchnic, leg, and nonsplanchnic upper body regions to systemic palmitate release did not differ between groups, although the last contributed the most (75%) to systemic palmitate release. Visceral fat area correlated with systemic palmitate flux (r = 0.45, P < 0.03) during both insulin infusions. We conclude that type 2 diabetes is associated with a generalized impairment in insulin suppression of lipolysis compared with equally obese ND individuals.