Urine AD7c-NTP Predicts Amyloid Deposition and Symptom of Agitation in Patients with Alzheimer's Disease and Mild Cognitive Impairment.
Urine AD7c-NTP Predicts Amyloid Deposition and Symptom of Agitation in Patients with Alzheimer's Disease and Mild Cognitive Impairment.
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尿液 AD7c-NTP 可预测阿尔茨海默病和轻度认知障碍患者的淀粉样蛋白沉积和躁动症状。
DOI：
10.3233/jad-170383
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Cheng Y
中科院分区：
文献类型：
--
作者：
Zhang N;Zhang L;Li Y;Gordon ML;Cai L;Wang Y;Xing M;Cheng Y
神经丝蛋白（NTP）的表达，这被认为是有关神经炎发芽和神经元死亡，可能会在脑组织，脑脊液，甚至尿液中阿尔茨海默病（AD）患者的升高。本研究分析了AD和轻度认知功能障碍（MCI）患者尿AD相关NTP（AD 7 c-NTP）水平、β淀粉样蛋白（Aβ）沉积与临床症状的相关性。招募了22名轻中度AD患者和8名MCI受试者。在所有参与者中，使用[11 C]标记的匹兹堡化合物B（Pi B）-正电子发射断层扫描（PET）测量Aβ沉积。使用酶联免疫吸附测定法测量尿AD 7 c-NTP水平。采用简易精神状态检查量表（MMSE）和神经精神量表（NPI）分别评定患者的认知功能和行为心理症状。14例（63.6%）AD患者和2例（25.0%）MCI受试者在PiB-PET上呈Aβ阳性。Aβ阳性受试者（2.27±2.22 ng/ml）和阴性受试者（0.55±0.60 ng/ml）之间的尿液AD 7 c-NTP水平存在显著差异（p = 0.018）。 以1.46 ng/ml为界值，68.8%的Aβ阳性受试者尿AD 7 c-NTP水平升高，92.9%的Aβ阴性受试者尿AD 7 c-NTP水平正常。 尿AD 7 c-NTP水平与MMSE和NPI总分无相关性。然而，AD 7 c-NTP水平与NPI上的激越评分呈正相关。尿AD 7 c-NTP预测认知功能障碍患者Aβ沉积的特异性高，敏感性中等。此外，尿AD 7 c-NTP水平与激越症状密切相关。
Expression of neuronal thread protein (NTP), which is considered to be related to neuritic sprouting and neuronal death, may be elevated in brain tissue, cerebrospinal fluid, and even urine in patients with Alzheimer’s disease (AD). In this study, we analyzed the correlation between urine AD-associated NTP (AD7c-NTP) level, and amyloid-β (Aβ) deposition, and clinical symptoms in AD and mild cognitive impairment (MCI). Twenty-two patients with mild to moderate AD and 8 subjects with MCI were recruited. Aβ deposition was measured with [11C]-labeled Pittsburgh compound B (PiB)-positron emission tomography (PET) in all participants. Urine AD7c-NTP levels were measured using enzyme-linked immunosorbent assay. Mini-Mental State Examination (MMSE) and Neuropsychiatric Inventory (NPI) were used to evaluate cognitive function and behavioral psychological symptoms, respectively. Fourteen (63.6%) of AD patients and 2 (25.0%) of MCI subjects were Aβ positive on PiB-PET. There was a significant difference in urine AD7c-NTP level between Aβ positive (2.27±2.22 ng/ml) and negative (0.55±0.60 ng/ml) subjects (p = 0.018). Using 1.46 ng/ml as a cut-off value, 68.8% of Aβ positive subjects showed elevated urine AD7c-NTP level, and 92.9% of Aβ negative subjects showed normal urine AD7c-NTP level. There were no relationships between urine AD7c-NTP level and MMSE and total NPI scores. However, AD7c-NTP level positively correlated with agitation score on NPI. Urine AD7c-NTP had high specificity and moderate sensitivity in predicting Aβ deposition among patients with cognitive impairment. Furthermore, urine AD7c-NTP level strongly correlated with the symptom of agitation.