Protein kinase C epsilon: an oncogene and emerging tumor biomarker.
Protein kinase C epsilon: an oncogene and emerging tumor biomarker.
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DOI：
10.1186/1476-4598-8-9
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发表时间：
2009-02-19
期刊：
影响因子：
37.3
通讯作者：
Pan Q
中科院分区：
文献类型：
--
作者：
Gorin MA;Pan Q
蛋白激酶C（PKC）家族成员因其在肿瘤发生中的作用长期以来一直受到研究。在这个丝氨酸/苏氨酸激酶家族的十种不同异构体中，蛋白激酶Cε（PKCε）因其作为一种转化癌基因的作用而被了解得最为透彻。在体外，已证明PKCε的过度表达会增加成纤维细胞或永生化上皮细胞的增殖、迁移和侵袭能力。此外，异种移植和转基因动物模型清楚地表明，PKCε的过度表达具有致瘤性，会导致转移性疾病。也许在表明ε异构体与肿瘤发生有关方面最重要的是，已发现PKCε在来自不同器官部位的肿瘤衍生细胞系和组织病理学肿瘤标本中过度表达。综合来看，这一系列研究提供了大量证据，表明PKCε是一种转化癌基因，在形成侵袭性转移表型中起着关键作用。本文综述了导致目前将PKCε理解为一种癌基因的相关文献。此外，本综述重点关注PKCε介导的细胞迁移信号网络，并探讨PKCε与三个主要的PKCε信号节点：RhoA/C、Stat3和Akt的相互作用。最后，讨论了PKCε作为肿瘤生物标志物的新兴作用。
Members of the protein kinase C (PKC) family have long been studied for their contributions to oncogenesis. Among the ten different isoforms of this family of serine/threonine kinases, protein kinase Cε (PKCε) is one of the best understood for its role as a transforming oncogene. In vitro, overexpression of PKCε has been demonstrated to increase proliferation, motility, and invasion of fibroblasts or immortalized epithelial cells. In addition, xenograft and transgenic animal models have clearly shown that overexpression of PKCε is tumorigenic resulting in metastatic disease. Perhaps most important in implicating the epsilon isoform in oncogenesis, PKCε has been found to be overexpressed in tumor-derived cell lines and histopathological tumor specimens from various organ sites. Combined, this body of work provides substantial evidence implicating PKCε as a transforming oncogene that plays a crucial role in establishing an aggressive metastatic phenotype. Reviewed here is the literature that has led to the current understanding of PKCε as an oncogene. Moreover, this review focuses on the PKCε-mediated signaling network for cell motility and explores the interaction of PKCε with three major PKCε signaling nodes: RhoA/C, Stat3 and Akt. Lastly, the emerging role of PKCε as a tumor biomarker is discussed.
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