Walking and Non-HDL-C in adults: a meta-analysis of randomized controlled trials.
Walking and Non-HDL-C in adults: a meta-analysis of randomized controlled trials.
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DOI：
10.1111/j.1520-037x.2005.3474.x
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发表时间：
2005-03
期刊：
影响因子：
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通讯作者：
G. Kelley;K. Kelley;Z. Tran
中科院分区：
文献类型：
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作者：
G. Kelley;K. Kelley;Z. Tran
非高密度脂蛋白胆固醇（non-HDL-C）水平升高是心血管疾病的主要危险因素。本研究的目的是使用荟萃分析方法来检查步行对成人非HDL-C的影响。来自948名受试者（573名运动，375名对照）的22项随机对照试验代表了30个结局，符合我们的纳入标准。在所有设计和类别中，与对照组相比，随机效应建模导致步行组的非HDL-C降低幅度显著更大，约为4%（平均值的+/-标准误，-5.6+/-1.8 mg/dL，95%置信区间，-8.8至-2.4 mg/dL）。荟萃回归分析显示非HDL-C变化与发表年份之间存在统计学显著相关性，最近发表年份相关性更大（R2 = 0.23，p = 0.005）。这项荟萃分析综述的结果表明，步行可以降低成年人的非HDL-C。
An elevated level of non-high-density lipoprotein cholesterol (non-HDL-C) is a major risk factor for cardiovascular disease. The purpose of this study was to use the meta-analytic approach to examine the effects of walking on non-HDL-C in adults. Twenty-two randomized controlled trials representing 30 outcomes from 948 subjects (573 exercise, 375 control) met our inclusion criteria. Across all designs and categories, random effects modeling resulted in a significantly greater decrease in the walking group when compared with the control group of approximately 4% for non-HDL-C (+/- standard error of the mean, -5.6+/-1.8 mg/dL, 95% confidence interval, -8.8 to -2.4 mg/dL). Meta-regression showed a statistically significant association between changes in non-HDL-C and the year of publication, with greater reductions associated with more recent publication year (R2 = 0.23, p = 0.005). The results of this meta-analytic review suggest that walking reduces non-HDL-C in adult humans.