Large-Pore Ultrasmall Mesoporous Organosilica Nanoparticles: Micelle/Precursor Co-templating Assembly and Nuclear-Targeted Gene Delivery
Large-Pore Ultrasmall Mesoporous Organosilica Nanoparticles: Micelle/Precursor Co-templating Assembly and Nuclear-Targeted Gene Delivery
复制标题
大孔超小介孔有机二氧化硅纳米颗粒：胶束/前体共模板组装和核靶向基因传递
DOI：
10.1002/adma.201404256
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发表时间：
2015-01-14
影响因子：
29.4
通讯作者：
Shi, Jianlin
中科院分区：
文献类型：
--
作者：
Wu, Meiying;Meng, Qingshuo;Shi, Jianlin
提出了一种新型的胶束/前驱体共模板组装方法，成功地合成了大孔、超小介孔有机硅纳米颗粒(MONS)。此外，精心设计的带有细胞穿透肽(TAT)的MONS(MONS-PTAT)被构建成高效的核内基因递送。它们具有较高的载药量，增强了对所载基因的保护，提高了EGFP质粒(PEGFP)的转染率。
A novel micelle/precursor co-templating assembly strategy is successfully developed to synthesize large-pore ultrasmall mesoporous organosilica nanoparticles (MONs). Furthermore, elaborately designed MONs with a cell-penetrating peptide (TAT) (MONs-PTAT) are constructed for highly efficient intranuclear gene delivery. They exhibit a high loading capacity, improved protection for the loaded gene, and enhanced transfection efficiencies of EGFP plasmid (pEGFP).