Age-related appearance of lamellar structures in lens capsule of cataractous eyes and its pathological significance
Age-related appearance of lamellar structures in lens capsule of cataractous eyes and its pathological significance
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白内障眼晶状体囊层状结构的年龄相关性表现及其病理意义
DOI：
10.1097/j.jcrs.0000000000000967
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Ken Hayashi
中科院分区：
文献类型：
--
作者：
Akira Hirata;Keiko Mine;Ken Hayashi
目的：为了确定形态学的变化，在透镜capsule与aging.Setting：Hayashi眼科医院，福冈，日本。设计：横断面study.Methods：25只眼睛从老年患者组（年龄80岁或以上）和25只眼睛从年轻患者组（年龄65岁或以下）谁被诊断为白内障，并表示为手术纳入研究。连续环形撕囊后，收集前透镜囊，立即固定，并进行电子显微镜分析。在扫描电子显微镜下观察前透镜囊横截面的背散射电子图像。观察并比较各组前透镜囊的超微结构。与层状结构的发生相关的因素也被确定，与层状结构的存在或不存在作为一个客观变量和术前临床特征作为解释variable.Results：50例50只眼。在年轻患者组中，20只眼（80%）具有均匀的透镜囊，而5只眼具有层状结构。相比之下，在老年患者组中，5只眼睛具有均匀的结构，而其余20只眼睛（80%）具有层状结构。1只眼出现囊膜分层。板层样结构的发生与年龄有关（P<0. 05）。结论：随着年龄的增长，前囊膜出现了层状结构。层状结构的出现表明透镜囊的脆弱性，这在某些情况下又可能导致囊分层或透镜脱位。
Purpose:To determine morphological changes in the lens capsule with aging.Setting:Hayashi Eye Hospital, Fukuoka, Japan.Design:Cross-sectional study.Methods:25 eyes from the older patient group (aged 80 years or older) and 25 eyes from the younger patient group (aged 65 years or younger) who were diagnosed with cataract and indicated for surgery were included in the study. After continuous curvilinear capsulorhexis, the anterior lens capsule was collected, immediately fixed, and processed for electron microscopy analysis. Backscattered electron images of the cross-section of the anterior lens capsule were observed under a scanning electron microscope. The ultrastructure of the anterior lens capsule was observed and compared between the groups. Factors associated with the occurrence of the lamellar structure were also identified, with the presence or absence of a lamellar structure as an objective variable and preoperative clinical characteristics as the explanatory variables.Results:50 eyes of 50 patients were included. In the younger patient group, 20 eyes (80%) had a homogeneous lens capsule, whereas 5 eyes had lamellar structures. By contrast, in the older patient group, 5 eyes had homogeneous structures, while the remaining 20 eyes (80%) had lamellar structures. 1 eye showed capsular delamination. The only significant factor for the occurrence of lamellar structures was age group (P<. 01, nominal logistic regression analysis).Conclusions:Lamellar structures appear in the anterior capsule during aging. The appearance of lamellar structures indicates fragility of the lens capsule, which may, in turn, lead to capsular delamination or lens dislocation in some cases.