CLINICAL AND PHARMACOLOGICAL INVESTIGATIONS OF NEW SALURETIC AZOSEMID
CLINICAL AND PHARMACOLOGICAL INVESTIGATIONS OF NEW SALURETIC AZOSEMID
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DOI：
10.1007/bf02089953
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发表时间：
1978-01-01
影响因子：
2.9
通讯作者：
KAUFMANN, B
中科院分区：
文献类型：
--
作者：
KRUCK, F;BABLOK, W;KAUFMANN, B
PLE 1053(阿佐塞米)是一种利尿剂，在化学和作用方式上与速尿相似。在静脉给药时，PLE 1053的体重约为速尿的5倍，其剂量-反应关系更密切，斜率更大。口服后，PLE 1053和速尿的效力大致相同。但在健康受试者中，阿佐塞米的作用时间相对较长，且未出现突变峰。
Ple 1053 (Azosemid) is a diuretic which resembles furosemide chemically and in its mode of action. When administered intravenously, Ple 1053 was approximately 5 times more potent on a weight basis than furosemide, its dose-response relationship was closer and the slope was steeper. After oral administration Ple 1053 and furosemide were approximately equal in potency. However, the effect of Azosemid in healthy subjects was relatively prolonged and abrupt peaks did not occur.