Characterizing brain oxygen metabolism in patients with multiple sclerosis with T2-relaxation-under-spin-tagging MRI
Characterizing brain oxygen metabolism in patients with multiple sclerosis with T2-relaxation-under-spin-tagging MRI
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DOI：
10.1038/jcbfm.2011.191
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发表时间：
2012-03-01
影响因子：
6.3
通讯作者：
Grossman, Robert I.
中科院分区：
文献类型：
--
作者：
Ge, Yulin;Zhang, Zhongwei;Grossman, Robert I.
在这项研究中，使用最近开发的自旋标记下 T2 松弛 (TRUST) 磁共振成像 (MRI) 评估多发性硬化症 (MS) 患者的静脉氧饱和度和氧代谢变化，该技术可测量上矢状静脉窦血氧饱和度 (Yv) 和脑氧代谢率 (CMRO2)（全球耗氧量指数）。使用 3 T MR 的 TRUST 对 30 名复发缓解型多发性硬化症患者和 30 名年龄匹配的健康对照进行了研究。患者的平均扩展残疾状态量表 (EDSS) 为 2.3（范围为 0 至 5.5）。我们发现，与健康对照受试者（60.2%+/- 4.0% 和 180.2 +/- 24.8 mu）相比，MS 患者的 Yv 显着增加（P < 0.0001），CMRO2 显着降低（P=0.003）（平均值 +/- 标准差：65.9%+/- 5.1% 和 138.8 +/- 35.4 mu mol 每 100 g/分钟）分别为每 100 克每分钟 mol），这意味着 MS 中的耗氧量减少。 MS 患者的 Yv 和 EDSS 以及 Yv 和病变负荷之间存在显着的正相关性 (n = 30)；相反，CMRO2 与 EDSS 之间以及 CMRO2 与病变负荷之间存在显着负相关（n = 12）。 Yv 和脑萎缩测量之间没有相关性。这项研究初步证明了 TRUST 在整体氧代谢中的潜在效用。我们关于多发性硬化症中氧气利用严重不足的结果提出了有关线粒体呼吸功能障碍和该疾病的神经变性的重要问题。脑血流与代谢杂志 (2012) 32, 403-412; doi：10.1038/jcbfm.2011.191； 2012 年 1 月 18 日在线发布
In this study, venous oxygen saturation and oxygen metabolic changes in multiple sclerosis (MS) patients were assessed using a recently developed T2-relaxation-under-spin-tagging (TRUST) magnetic resonance imaging (MRI), which measures the superior sagittal venous sinus blood oxygenation (Yv) and cerebral metabolic rate of oxygen (CMRO2), an index of global oxygen consumption. Thirty patients with relapsing-remitting MS and 30 age-matched healthy controls were studied using TRUST at 3 T MR. The mean expanded disability status scale (EDSS) of the patients was 2.3 (range, 0 to 5.5). We found significantly increased Yv (P < 0.0001) and decreased CMRO2 (P=0.003) in MS patients (mean +/- s.d.: 65.9%+/- 5.1% and 138.8 +/- 35.4 mu mol per 100 g per minute) as compared with healthy control subjects (60.2%+/- 4.0% and 180.2 +/- 24.8 mu mol per 100 g per minute, respectively), implying decrease of oxygen consumption in MS. There was a significant positive correlation between Yv and EDSS and between Yv and lesion load in MS patients (n = 30); on the contrary, there was a significant negative correlation between CMRO2 and EDSS and between CMRO2 and lesion load (n = 12). There was no correlation between Yv and brain atrophy measures. This study showed preliminary evidence of the potential utility of TRUST in global oxygen metabolism. Our results of significant underutilization of oxygen in MS raise important questions regarding mitochondrial respiratory dysfunction and neurodegeneration of the disease. Journal of Cerebral Blood Flow & Metabolism (2012) 32, 403-412; doi: 10.1038/jcbfm.2011.191; published online 18 January 2012