Anterior Cingulate cortical neuronal activity during perception of noxious thermal stimuli in monkeys
Anterior Cingulate cortical neuronal activity during perception of noxious thermal stimuli in monkeys
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DOI：
10.1152/jn.00190.2005
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发表时间：
2005-09-01
影响因子：
2.5
通讯作者：
Kitagawa, J
中科院分区：
文献类型：
--
作者：
Iwata, K;Kamo, H;Kitagawa, J
据报道，前扣带皮层（ACC）具有多种与疼痛以及疼痛感知相关的功能。然而，这些职能的基本机制仍不清楚。为了阐明ACC在疼痛感知和疼痛相关功能（如注意疼痛和逃避疼痛）中的功能作用，从ACC记录单个神经元活动，并研究该神经元活动的行为相关性。在清醒行为猴子的ACC中总共记录了667个神经元。其中21人在热探测任务中进行了调制活动。其中18个增加了他们的射击频率增加刺激温度，而其中三个减少了射击加热的脸。75%的热反应ACC神经元的热诱发反应显着抑制时，猴子检测到的变化幅度的照明的前面板上呈现的光。当猴子从有害的热刺激中逃脱时，神经元活动明显高于猴子检测到温度（T2）在较大的初始偏移（T1）之上的微小变化时。未观察到T2刺激的放电频率和检测潜伏期之间的关系。这些结果表明，ACC伤害性神经元参与注意疼痛和逃避疼痛，但不参与疼痛的感觉辨别方面。
It has been reported that the anterior cingulate cortex (ACC) has a variety of functions relating to pain as well as pain perception. However, the underlying mechanisms for those functions remain unclear. To elucidate the functional role of the ACC in pain perception and pain-related functions such as attention to pain and escape from pain, single neuronal activity was recorded from the ACC, and the behavioral correlates of this neuronal activity was studied. A total of 667 neurons were recorded from the ACC in awake behaving monkeys. Twenty-one had modulated activity during a heat-detection task. Eighteen of these increased their firing frequency following an increase in stimulus temperature, whereas three of them had decreased firing during heating of the face. Seventy-five percent of heat-evoked responses of heat-responsive ACC neurons were significantly depressed when monkeys detected the change in magnitude of illumination of a light presented on the front panel. The neuronal activity was significantly higher when monkeys escaped from a noxious heat stimulus than when the monkeys detected a small change in temperature (T2) above a larger initial shift (T1). No relationship between firing frequency and detection latency of the T2 stimulation was observed. These findings suggest that ACC nociceptive neurons are involved in attention to pain and escape from pain but not in the sensory discriminative aspect of pain.