Cellular distribution of the iron-binding protein lactotransferrin in the mesencephalon of Parkinson's disease cases
Cellular distribution of the iron-binding protein lactotransferrin in the mesencephalon of Parkinson's disease cases
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DOI：
10.1007/s004010050468
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发表时间：
1996-06-01
影响因子：
12.7
通讯作者：
Hof, PR
中科院分区：
文献类型：
--
作者：
Leveugle, B;Faucheux, BA;Hof, PR
最近，在各种神经退行性疾病期间，中枢神经系统中铁结合蛋白乳转铁蛋白的分布发生了变化。为了研究乳转铁蛋白是否与帕金森病的神经病理变化相关，我们使用定量免疫组织化学方法分析了该蛋白在神经正常个体和帕金森病患者中脑中的分布。在对照病例黑质的大量神经元中观察到高水平的乳转铁蛋白。乳转铁蛋白阳性神经元受到帕金森病中发生的神经退行性过程的严重影响，所有这些病例中免疫标记神经元数量的严重减少表明了这一点。定量分析还表明，与对照病例相比，帕金森病病例黑质和腹侧被盖区幸存神经元中乳转铁蛋白的免疫标记水平较高。这些结果表明乳转铁蛋白可能积极参与帕金森病神经元变性的机制。
Changes in the distribution of the iron-binding protein lactotransferrin have recently been described in the central nervous system during a variety of neurodegenerative disorders. To investigate whether lactotransferrin is associated with the neuropathological changes that characterize Parkinson's disease, we analyzed the distribution of this protein in the mesencephalon of neurologically normal individuals and patients affected with Parkinson's disease using quantitative immunohistochemical methods. High levels of lactotransferrin were observed in a large population of neurons in the substantia nigra of control cases. Lactotransferrin-positive neurons were severely affected by the neurodegenerative process that occurs in Parkinson's disease as indicated by a severe decrease in the number of immunolabeled neurons in all of these cases. Quantitative analysis also demonstrated higher immunolabeling levels of lactotransferrin in the surviving neurons in the substantia nigra and ventral tegmental area of Parkinson's disease cases compared to control cases. These results suggest that lactotransferrin may participate actively in the mechanism of neuronal degeneration in Parkinson's disease.