Association between homocysteine and obesity: A meta-analysis
Association between homocysteine and obesity: A meta-analysis
复制标题
同型半胱氨酸与肥胖之间的关联：荟萃分析
DOI：
10.1111/jebm.12412
复制
发表时间：
2021-09-01
影响因子：
7.3
通讯作者：
Ma, Lanqing
中科院分区：
文献类型：
--
作者：
Wang, Jinxiang;You, Dingyun;Ma, Lanqing
根据以前对肥胖的研究，我们发现同型半胱氨酸浓度和肥胖之间的关系是有争议的。因此，我们进行了这项荟萃分析来调查这种关联。我们检索了PubMed、Cochrane图书馆和EMBASE数据库，以评估从开始到2019年3月同型半胱氨酸浓度与肥胖之间关系的研究。所有纳入研究的质量采用纽卡斯尔渥太华量表（NOS）和卫生保健研究质量机构（AHRQ）进行评估。采用RevMan5.3软件和Stata12.0软件进行数据分析。采用标准化平均差异（SMD）和相应的95%置信区间（95% ci）作为效应大小的度量，通过荟萃分析评估同型半胱氨酸浓度与肥胖之间的关系。P < 0.05为显著性水平。我们的荟萃分析最终纳入了14项研究。对14项研究的荟萃分析发现，无论营养状况、饮食习惯、胰岛素抵抗（IR）状况、特殊病史、用药史、遗传背景等，对照组同型半胱氨酸浓度均显著低于肥胖患者（SMD = 0.76, 95% CI = 0.25-1.27, P I-2 = 94%，异质性P < 0.01）。非肥胖多囊卵巢综合征（PCOS）患者的同型半胱氨酸浓度低于肥胖多囊卵巢综合征（PCOS）患者（SMD = 0.48, 95% CI = 0.20-0.77, P I-2 = 39%，异质性P = 0.18）。我们的荟萃分析结果显示，肥胖患者的同型半胱氨酸浓度显著升高。
According to previous studies of obesity, we found that the association between homocysteine concentrations and obesity was reported controversially. Thus, we carried out this meta-analysis to investigate this association. We searched PubMed, The Cochrane library, and EMBASE database for studies that evaluate the relationship between homocysteine concentrations and obesity from inception to March, 2019. The quality of all included studies was assessed by the Newcastle Ottawa Scale (NOS) and the Agency for Healthcare Research Quality (AHRQ). The RevMan5.3 software and Stata12.0 software were used for conducting all data analyses. Standardized mean differences (SMD) with the corresponding 95% confidence intervals (95% CIs) were used as a measure of effect size to assess the relationship between homocysteine concentrations and obesity through a meta-analysis. The level of significance was set at P < .05. A total of 14 studies were ultimately included in our meta-analysis. Meta-analysis of the 14 studies found remarkable lower homocysteine concentrations in controls than in obese patients (SMD = 0.76, 95% CI = 0.25-1.27, P I-2 = 94% and P < .01 for heterogeneity), regardless of nutritional status, dietary habit, insulin resistance (IR) status, special disease history, history of medicine taken, genetic background, and so on. Homocysteine concentrations in nonobese patients with polycystic ovarian syndrome (PCOS) were lower than obese patients with PCOS (SMD = 0.48, 95% CI = 0.20-0.77, P I-2 = 39% and P = .18 for heterogeneity). The result of our meta-analysis showed that homocysteine concentrations were significantly elevated among obese patients.