Association of IRF5 polymorphism with MPO-ANCA-positive vasculitis in a Japanese population
Association of IRF5 polymorphism with MPO-ANCA-positive vasculitis in a Japanese population
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DOI：
10.1038/gene.2013.45
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发表时间：
2013-12-01
影响因子：
5
通讯作者：
Tsuchiya, N.
中科院分区：
文献类型：
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作者：
Kawasaki, A.;Inoue, N.;Tsuchiya, N.
干扰素调节因子 5 (IRF5) 和信号转导和转录激活因子 4 (STAT4) 是多种自身免疫性疾病的共有易感基因。在这项研究中，我们。研究了这些基因是否也导致日本人群对抗中性粒细胞胞浆抗体（ANCA）相关血管炎（AAV）的易感性。对 232 名日本髓过氧化物酶（MPO）-ANCA 阳性 AAV 患者（包括 177 名显微镜下多血管炎和 710 名健康对照）进行了 IRF5 rs10954213 和 STAT4 rs7574865 的病例对照研究。 IRF5 rs10954213G 在 MPO-ANCA 阳性 AAV 中显着增加（相加模型，P=0.023，比值比=1.27，95% 置信区间=1.03-1.57）。先前显示风险等位基因与较低的 mRNA 水平相关。 IRF5 的。另一方面，未检测到 STAT4 rs7574865T 与 AAV 的显着关联。这些观察。表明 IRF5 可能导致日本人群对 MPO-ANCA 阳性 AAV 的易感性。
Interferon regulatory factor 5 (IRF5) and signal transducer and activator of transcription 4 (STAT4) are shared susceptibility genes for various autoimmune diseases. In this study, we. investigated whether these genes also contribute to susceptibility to anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a Japanese population. A case-control study was Carried out on IRF5 rs10954213 and STAT4 rs7574865 in 232 Japanese myeloperoxidase (MPO)-ANCA-positive AAV patients, including 177 microscopic polyangiitis and 710 healthy controls. IRF5 rs10954213G was significantly increased in MPO-ANCA-positive AAV (additive model, P=0.023, odds ratio=1.27, 95% confidence interval=1.03-1.57). The risk allele was previously shown to be associated with lower mRNA level. of IRF5. On the other hand, significant association of STAT4 rs7574865T with AAV was not detected. These observations. suggested that IRF5 may contribute to susceptibility to MPO-ANCA-positive AAV in a Japanese population.