Prospects for microbeam radiation therapy of brain tumours in children to reduce neurological sequelae
Prospects for microbeam radiation therapy of brain tumours in children to reduce neurological sequelae
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DOI：
10.1111/j.1469-8749.2007.00577.x
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发表时间：
2007-08-01
影响因子：
3.8
通讯作者：
Slatkin, D. N.
中科院分区：
文献类型：
--
作者：
Laissue, J. A.;Blattmann, H.;Slatkin, D. N.
微束放射治疗（MRT）是一种使用多个平行的、平面的、微米宽的、同步加速器产生的x射线束（“微束”）对肿瘤进行实验性放射外科手术的形式，它可以安全地向连续的正常动物组织提供辐射剂量，远远高于任何标准毫米宽的放射外科光束对动物或患者的相同正常组织所耐受的最大剂量。一组平行的微光束，即使剂量对放射敏感的发育组织（例如小鸡的绒毛膜尿囊膜）几乎没有损害，也能抑制啮齿动物的生长或消融一些移植的恶性肿瘤。在法国格勒诺布尔的欧洲同步辐射设施，使用与6GeV电子同步加速器环相切的ID17 wiggler束线，用同步加速器产生的一系列平行x射线微光束照射100只20至38克的正常哺乳斯普拉格-道利大鼠幼崽和13只5至12公斤的正常断奶约克郡仔猪的小脑，剂量与mrt相关范围重叠（约50-600Gy）。随后对大多数动物进行的至少1年的良好发展表明，与目前使用更宽的光束相比，MRT可能用于治疗儿童脑肿瘤，对中枢神经系统发育的风险更小。
Microbeam radiation therapy (MRT), a form of experimental radiosurgery of tumours using multiple parallel, planar, micrometres-wide, synchrotron-generated X-ray beams ('microbeams'), can safely deliver radiation doses to contiguous normal animal tissues that are much higher than the maximum doses tolerated by the same normal tissues of animals or patients from any standard millimetres-wide radiosurgical beam. An array of parallel microbeams, even in doses that cause little damage to radiosensitive developing tissues, for example, the chick chorioallantoic membrane, can inhibit growth or ablate some transplanted malignant tumours in rodents. The cerebella of 100 normal 20 to 38g suckling Sprague-Dawley rat pups and of 13 normal 5 to 12kg weanling Yorkshire piglets were irradiated with an array of parallel, synchrotron-wiggler-generated X-ray microbeams in doses overlapping the MRT-relevant range (about 50-600Gy) using the ID17 wiggler beamline tangential to the 6GeV electron synchrotron ring at the European Synchrotron Radiation Facility in Grenoble, France. Subsequent favourable development of most animals over at least 1 year suggests that MRT might be used to treat children's brain tumours with less risk to the development of the central nervous system than is presently the case when using wider beams.