Using p53-immunostained large specimens to determine the distal intramural spread margin of rectal cancer
Using p53-immunostained large specimens to determine the distal intramural spread margin of rectal cancer
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DOI：
10.3748/wjg.v12.i10.1626
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发表时间：
2006-03-14
影响因子：
4.3
通讯作者：
Wang, Fu-Long
中科院分区：
文献类型：
--
作者：
Pan, Zhi-Zhong;Wan, De-Sen;Wang, Fu-Long
目的：确定直肠癌远端壁内扩散（DIS）的边界。常规苏木精-伊红（H&E）染色后，用免疫组化方法检测直肠癌大标本DIS边缘。将患者分为A、13、C、D组。结果：61例患者中51例（83.6%）存在DIS，DIS范围为0.11- 3.5cm，H&E染色法测量DIS平均值为0.13cm。两组均数比较差异有显著性（t=5.622，P
AIM: To determine the distal intramural spread (DIS) margin of rectal cancer.METHODS: Sixty-one p53-positive specimens of rectal cancer were used. After conventional hematoxylin and eosin (H&E) staining, the DIS margin of rectal cancer in large specimens was examined by immunohistochemistry. The patients were divided into A, 13, C, and D groups. After a long-term follow-up, the survival curves of the four groups were estimated using the life table.RESULTS: Fifty-one of the sixty-one cases (83.6%) had DIS. The extent of DIS ranged 0.11-3.5 cm; meanwhile the mean of DIS measured by H&E staining was 0.13 cm. The significant difference was found between the means (t=5.622, P