Relationship between noradrenaline-induced depolarization and contraction in vascular smooth muscle.
Relationship between noradrenaline-induced depolarization and contraction in vascular smooth muscle.
复制标题
去甲肾上腺素诱导的血管平滑肌去极化与收缩之间的关系。
DOI：
10.1159/000158152
复制
发表时间：
1978
期刊：
影响因子：
--
通讯作者：
G. Haeusler
中科院分区：
文献类型：
--
作者：
G. Haeusler
在兔主肺动脉条中，分别在正常条件下以及用士的宁和四乙铵增加和降低膜电位后，获得了去甲肾上腺素对血管平滑肌细胞机械和电反应的完整剂量 - 反应曲线。结果表明，去甲肾上腺素诱导的收缩幅度与膜电位的高度有关，而与肾上腺素能递质产生的去极化程度无关。
In strips of rabbit main pulmonary artery, full dose-response curves of noradrenaline for the mechanical and electrical responses of the vascular smooth muscle cells were obtained under normal conditions and after increasing and decreasing the membrane potential with strychnine and tetraethylammonium, respectively. The results suggest that the magnitude of the noradrenaline-induced contraction is related to the height of the membrane potential and not to the degree of depolarization produced by the adrenergic transmitter.