Serological Detection of Antibodies to Peste des Petits Ruminants Virus in Large Ruminants.
Serological Detection of Antibodies to Peste des Petits Ruminants Virus in Large Ruminants.
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DOI：
10.1111/tbed.12392
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发表时间：
2017-04
影响因子：
4.3
通讯作者：
Parida S
中科院分区：
文献类型：
--
作者：
Abubakar M;Mahapatra M;Muniraju M;Arshed MJ;Khan EH;Banyard AC;Ali Q;Parida S
小反刍兽疫（Peste des Petits Ruminants，PPR）是一种经济上重要的小反刍动物疾病，其地理分布迅速扩大。小反刍兽疫病毒可以以多种方式表现为从急性到亚临床的疾病。我们通过评估动物群的血清学状态，调查了在病毒在小型反刍动物群体中流行的地区，大型反刍动物对PPRV的暴露情况。这项研究的重点是巴基斯坦的旁遮普省，该地区是病毒流行的地区，混合养殖方式的发生使小型和大型反刍动物种群之间的密切相互作用。在10.0%的牛和14.16%的水牛中检测到总体PPR血清阳性。在对不同年龄组的大型反刍动物的血清学特征进行评估后，在2岁以上的牛（17.5%）和水牛（22.5%）中观察到最大血清阳性率，表明对大型反刍动物群体进行采样用于PPR血清监测的潜在效用。在1 - 2岁之间采样的大型反刍动物在群体内具有相似的血清阳性水平，分别为11.2%和16.2%的动物血清阳性。目前的PPR疫苗接种策略不能区分感染和接种的小反刍动物，因此，绵羊和山羊的血清学监测价值不大。在考虑根除PPRV方案时，这一因素具有重要意义。然而，在大型和小型反刍动物一起饲养的情况下，大型反刍动物的血清学监测可以提供存在轻度疾病或定期接种小型反刍动物的人群中病毒感染的快照。
Peste des petits ruminants (PPR) is an economically important disease of small ruminants with a rapidly expanding geographical distribution. Peste des petits ruminants virus may manifest in a variety of ways with disease ranging from acute to subclinical. We investigated the exposure of large ruminants to PPRV in areas where the virus is endemic in the small ruminant population by assessing the serological status of groups of animals. This study focused on the Punjab province of Pakistan as an area where the virus is endemic and where mixed farming practices occur enabling close interactions between small and large ruminant populations. An overall PPR seropositivity was detected in 10.0% of cattle and 14.16% of buffaloes. Following an assessment of serological profiles in large ruminants within different age groups, a maximum seroprevalence was observed in cattle (17.5%) and buffaloes (22.5%) over 2 years of age indicating the potential utility of sampling large ruminant populations for PPR serosurveillance. The large ruminants sampled between one and two years of age had similar levels of seropositivity within populations with 11.2% and 16.2% of animals being seropositive, respectively. Current PPR vaccination strategies do not enable the differentiation between infected and vaccinated small ruminants, and as such, the serological surveillance of sheep and goats is of little value. When considering eradication programmes for PPRV, this factor is of great significance. However, where large and small ruminants are farmed together, serological surveillance of large ruminants may provide a snapshot of virus infection within populations where mild disease is present or where small ruminants are regularly vaccinated.