Novel Concise Synthesis of (±)-Noviose and L-(+)-Noviose by Palladium-Catalyzed Epoxide Opening
Novel Concise Synthesis of (±)-Noviose and L-(+)-Noviose by Palladium-Catalyzed Epoxide Opening
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DOI：
10.1055/s-0030-1258475
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发表时间：
2011-04-01
影响因子：
2.6
通讯作者：
Kino, Jun
中科院分区：
文献类型：
--
作者：
Matsushima, Yoshitaka;Kino, Jun
我们建立了一种新的、简洁的合成路线，以获得氨基香豆素类抗生素的脱氧糖成分noviose。L-(+)- noviose是利用钯催化的环氧化合物开孔反应和随后的内酯生成作为关键反应，从非糖手性环氧化合物开始，以两种对映体形式容易获得。
We established a novel, concise synthetic route for obtaining noviose, the deoxy sugar component of aminocoumarin antibiotics. L-(+)-Noviose was successfully synthesized by utilizing a palladium-catalyzed epoxide-opening reaction and the subsequent lactone formation as key reactions, starting from a nonsugar chiral epoxide, which is easily available in both enantiomeric forms.