Actomyosin, collagen, and cell hypertrophy in intestinal muscle after jejunoileal bypass.
Actomyosin, collagen, and cell hypertrophy in intestinal muscle after jejunoileal bypass.
复制标题
空肠绕道术后肠肌中的肌动球蛋白、胶原蛋白和细胞肥大。
DOI：
10.1152/ajpgi.1986.250.1.g70
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Weisbrodt,NW
中科院分区：
文献类型：
--
作者：
Bowers,RL;Eeckhout,C;Weisbrodt,NW
先前的观察表明，大鼠小肠70%的旁路诱导不连续段和旁路段的浆肌质量增加。本研究的目的是量化肌层中肌动球蛋白和胶原蛋白的量，并确定空回肠旁路术后小肠不同位置环形肌层每个横截面积的细胞数。与对照组相比，肥大组织中肌动球蛋白相对于总组织蛋白的量保持不变，肌动蛋白与肌球蛋白的比例相似。假手术和旁路手术动物组织的每湿重胶原蛋白含量往往低于未手术对照组的组织，并且在远端不连续位置显著更低。旁路动物所有位置的组织中单位横截面积的细胞数量均减少。这些发现支持了这样的假设，即肠旁路术后浆肌质量的增加是由于功能性平滑肌组织的增加，并且至少部分增加是由于细胞肥大。
Previous observations indicate that bypass of 70% of the small bowel of rats induces increases in the seromuscular mass of both the in-continuity and the bypassed segment. The purpose of this study was to quantify the amount of actomyosin and collagen in the muscle layer and to determine the number of cells per cross-sectional area of the circular muscle layer at various locations of the small intestine after jejunoileal bypass. The amount of actomyosin relative to total tissue protein remained the same in the hypertrophied tissues compared with controls, and the actin-to-myosin ratios were similar. The collagen content per wet weight of the tissue from the sham- and bypass-operated animals tended to be less than in tissue from unoperated controls and was significantly less at the distal in-continuity location. The number of cells per cross-sectional area was decreased in tissues from all locations of the bypassed animals. These findings support the hypothesis that the increase in seromuscular mass after intestinal bypass is due to an increase in functioning smooth muscle tissue and that at least part of the increase is due to cell hypertrophy.