Effect of thyroidectomy and thyroxine on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunotoxicity.
Effect of thyroidectomy and thyroxine on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunotoxicity.
复制标题
甲状腺切除术和甲状腺素对 2,3,7,8-四氯二苯并-对二恶英诱导的免疫毒性的影响。
DOI：
10.1016/0024-3205(85)90175-4
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发表时间：
1985
期刊：
影响因子：
6.1
通讯作者：
Rozman,KK
中科院分区：
文献类型：
--
作者：
Pazdernik,TL;Rozman,KK
放射性甲状腺切除术对2，3，7，8-四氯二苯并-对-二恶英（TCDD_）诱导的大鼠免疫毒性的保护作用通过脾抗SRBC空斑形成细胞测定来评估。甲状腺素（T4）替代治疗可部分逆转甲状腺切除对T4和T3血清水平、体重和免疫功能的影响，并恢复TCDD诱导的免疫毒性。因此，TCDD暴露诱导的甲状腺功能减退症可被视为机体减少TCDD损伤的一种保护性反应。
Radiothyroidectomy protected against 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD_-induced immunotoxicity in rats as assessed by the spleen anti-SRBC plaque-forming cell assay. Thyroxine (T4) replacement therapy partially reversed the effects of thyroidectomy on T4and triiodothyronine (T3) serum levels, body weight and immune function as well as restored TCDD-induced immunotoxicity. Thus, hypothyroidism induced by TCDD exposure can be viewed as a protective response of the organism to reduce the insult caused by TCDD.