Demographic and clinical characteristics of cutaneous lupus erythematosus at a paediatric dermatology referral centre
Demographic and clinical characteristics of cutaneous lupus erythematosus at a paediatric dermatology referral centre
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DOI：
10.1111/bjd.12383
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发表时间：
2013-08-01
影响因子：
10.3
通讯作者：
Chiu, Y. E.
中科院分区：
文献类型：
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作者：
Dickey, B. Z.;Holland, K. E.;Chiu, Y. E.
背景：儿科皮肤红斑狼疮(CLE)在文献中并不常见，描述也不充分。与成人相似，患有CLE的儿童会出现LE特异性和/或LE非特异性皮肤表现。目的详细描述儿童CLE的人口学特征和临床特征，并与成人文献报道的结果进行比较。方法对53例在儿科皮肤科门诊就诊的儿童皮肤CLE的临床表现进行回顾性分析。从盘状红斑狼疮进展到系统性红斑狼疮(SLE)在我们的队列中没有发生。亚急性CLE的患者比成人更有可能有腰部以下的病变以及伴随的SLE。结论儿童CLE具有不同的临床表现和进展，可能与成人疾病不同。具体来说，患有急性和亚急性CLE的儿童可能比成人更有可能患有全身性疾病；因此，应该密切监测这些亚型的患者是否有SLE的证据。研究的局限性包括患者人数较少，这可能会限制推广这些数据的能力，以及相对较短的随访间隔。
Background Paediatric cutaneous lupus erythematosus (CLE) is uncommon and inadequately described in the literature. Similar to adults, children with CLE develop LE-specific and/or LE-nonspecific skin findings. Similarities and differences in demographics and clinical course between paediatric and adult CLE have not been sufficiently described.Objectives To detail the demographic and clinical features of paediatric CLE and compare these findings with those reported in the adult literature.Methods A retrospective chart review was performed of 53 children seen in a paediatric dermatology clinic with cutaneous manifestations of LE.Results Patients presented with all five major subtypes of CLE, with some notable differences from adult CLE and previously published reports of paediatric CLE. Progression from discoid LE to systemic LE (SLE) did not occur in our cohort. Patients with subacute CLE were more likely than adults to have lesions below the waist as well as concomitant SLE. Sex distribution for CLE in our study was equal prior to puberty and female predominant in post-pubertal patients.Conclusions Children with CLE have variable clinical presentations and progression to SLE that may be different from adult disease. Specifically, children with acute and subacute CLE may be more likely than adults to have systemic disease; therefore, patients with these subtypes should be monitored closely for evidence of SLE. Study limitations included small patient numbers that may limit the ability to generalize these data and relatively short follow-up intervals.