The role of plasma lipoprotein lipase, hepatic lipase and GPIHBP1 in the metabolism of remnant lipoproteins and small dense LDL in patients with coronary artery disease.
The role of plasma lipoprotein lipase, hepatic lipase and GPIHBP1 in the metabolism of remnant lipoproteins and small dense LDL in patients with coronary artery disease.
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DOI：
10.1016/j.cca.2017.11.021
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Yuji Muraba;T. Koga;Y. Shimomura;Y. Ito;Y. Hirao;J. Kobayashi;Takao Kimura;K. Nakajima;M. Murakami
中科院分区：
文献类型：
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作者：
Yuji Muraba;T. Koga;Y. Shimomura;Y. Ito;Y. Hirao;J. Kobayashi;Takao Kimura;K. Nakajima;M. Murakami
背景冠心病患者血浆脂蛋白脂酶(LPL)、肝甘油三酯脂酶(HTGL)、糖基磷脂酰肌醇锚定高密度脂蛋白结合蛋白1(GPIHBP1)浓度与残余脂蛋白(RLP)和小密度脂蛋白(SdLDL)代谢的关系尚不完全清楚。用双抗体夹心法测定血浆LPL、HTGL和GPIHBP1浓度。结果LPL浓度与高密度脂蛋白胆固醇呈显著正相关，与甘油三酯、RLP-C呈负相关。HTGL浓度与RLP-C、sdLDL-C呈正相关。冠心病组肝素前/肝素后血浆hTGL比值及sdLDL-C/LDL-C比值显著高于非冠心病组。GPIHBP1与LPL呈正相关，与RLP-C、sdLDL-C呈负相关。结论HTGL浓度与RLP-C、sdLDL-C呈正相关，而LPL、GPIHBP1与RLP-C、sdLDL-C呈负相关。这些结果表明，HTGL升高与冠心病风险增加相关，而LPL升高与CAD风险降低相关。
BackgroundThe relationship between plasma lipoprotein lipase (LPL), hepatic triglyceride lipase (HTGL), glycosylphosphatidylinositol anchored HDL binding protein1 (GPIHBP1) concentration and the metabolism of remnant lipoproteins (RLP) and small dense LDL (sdLDL) in patients with coronary artery disease (CAD) is not fully elucidated.MethodsOne hundred patients who underwent coronary angiography were enrolled. The plasma LPL, HTGL and GPIHBP1 concentrations were determined by ELISA. The time dependent changes in those lipases, lipids and lipoproteins were studied at a time-point just before, and 15 min, 4 h and 24 h after heparin administration.ResultsThe LPL concentration exhibited a significant positive correlation with HDL-C, and inversely correlated with TG and RLP-C. The HTGL concentration was positively correlated with RLP-C and sdLDL-C. The HTGL ratio of the pre-heparin/post-heparin plasma concentration and sdLDL-C/LDL-C ratio were significantly greater in CAD patients than in non-CAD patients. GPIHBP1 was positively correlated with LPL and inversely correlated with RLP-C and sdLDL-C.ConclusionThe HTGL concentration was positively correlated with RLP-C and sdLDL-C, while LPL and GPIHBP1 were inversely correlated with RLP-C and sdLDL-C. These results suggest that elevated HTGL is associated with increased CAD risk, while elevated LPL is associated with a reduction of CAD risk.