Association between Visceral Adiposity Index and hypertension among Chinese Adults: a nationwide cross-sectional study in the China Health and Nutrition Survey
Association between Visceral Adiposity Index and hypertension among Chinese Adults: a nationwide cross-sectional study in the China Health and Nutrition Survey
复制标题
中国成人内脏脂肪指数与高血压的关联：中国健康与营养调查的全国横断面研究
DOI：
10.1097/mbp.0000000000000469
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发表时间：
2020-10-01
影响因子：
1.3
通讯作者：
Zhou, Yafeng
中科院分区：
文献类型：
--
作者：
Yang, Jing;Li, Hongxia;Zhou, Yafeng
内脏脂肪指数（VAI）是内脏脂肪功能的指标。它显示了与心脏代谢风险的密切联系，但尚不清楚VAI是否与高血压有关。目的探讨中国成人VAI与高血压的关系。方法利用2009年中国健康与营养调查数据，对5421名中国成年人进行横断面分析。进行多变量logistic回归和线性回归以确认相关性。结果多因素Logistic回归分析显示，VAI与高血压发病风险呈剂量-反应关系（P <0.01）。与第一个四分位数相比，第二个四分位数中发生高血压的性别和年龄调整优势比（OR）[95%置信区间（CI）]为1.06（0.90-1.26），第三个四分位数为1.09（0.92-1.29），第四个四分位数为1.28（1.08-1.52）。多元线性回归分析显示，VAI与收缩压（β = 0.37; 95%CI，0.13-0.62; P = 0.0028）和舒张压（β = 0.26; 95%CI，0.12-0.40; P = 0.0004）呈正相关。亚组分析显示，在载脂蛋白A1 ≥1.2 g/L（P = 0.0115）或血红蛋白A1 c ≥6.5%（P = 0.0369）的参与者中，VAI与高血压呈正相关。结论VAI与中国成年人群高血压呈正相关，可作为中国人群高血压危险性的一个指标。
Background Visceral Adiposity Index (VAI) is an indicator of visceral adipose function. It showed an intense association with cardiometabolic risks, but it is unclear whether VAI is associated with hypertension. Objective We aim to determine the association of VAI with hypertension in Chinese adults. Methods We carried out a cross-sectional analysis of 5421 Chinese adults based on data which was from the China Health and Nutrition Survey (CHNS) 2009. Multivariable logistic regression and linear regression were performed to confirm the association. Results In multivariable logistic regression analysis, there was a dose-response association between VAI and the risk of incident hypertension (P for trend <0.01). The sex and age-adjusted odds ratios (ORs) [95% confidence interval (CI)] for the development of hypertension were 1.06 (0.90–1.26) in the second, 1.09 (0.92–1.29) in the third, and 1.28 (1.08–1.52) in the fourth VAI quartile, compared to the first quartile. The multivariable linear regression analysis indicated that VAI was positive association with systolic blood pressure (β = 0.37; 95% CI, 0.13–0.62; P = 0.0028) and diastolic blood pressure (β = 0.26; 95% CI, 0.12–0.40; P = 0.0004). The subgroup analysis showed that VAI had more positive association with hypertension in participants with an apolipoprotein A1 of ≥1.2 g/L (P = 0.0115) or a hemoglobin A1c of ≥6.5% (P = 0.0369). Conclusions VAI was positively associated with hypertension among the Chinese adult population, and it may assume an indicator of hypertension risk for the Chinese population.