Increased rate of tolbutamide metabolism in alcoholic patients.
Increased rate of tolbutamide metabolism in alcoholic patients.
复制标题
酗酒患者的甲苯磺丁脲代谢率增加。
DOI：
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发表时间：
1969
期刊：
影响因子：
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通讯作者：
F. Iber
中科院分区：
文献类型：
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作者：
R. Kater;F. Tobon;F. Iber
在一项对照人体研究中发现，在酗酒患者中，甲苯丁胺的生物半衰期减少了两倍以上。我们认为这种作用是酒精刺激人肝脏中负责代谢甲磺丁胺的肝微粒体酶系统的结果。其他治疗药物的代谢也可能受到酒精的类似影响，这可能导致对药物治疗的反应不正常。
In a controlled human study the biological half-life of tolbutamide was found to be reduced more than twofold in alcoholic patients. We suggest that this effect is the result of stimulation by alcohol of a hepatic microsomal enzyme system in the human liver responsible for the metabolism of tolbutamide. The metabolism of other therapeutic agents could be similarly affected by alcohol, and this might lead to irregularities in response to drug treatment.