Protein Production and Secretion in Exocrine Cells
Protein Production and Secretion in Exocrine Cells
复制标题
外分泌细胞中蛋白质的产生和分泌
DOI：
10.1177/00220345870660s105
复制
发表时间：
1987
影响因子：
7.6
通讯作者：
R. Cameron
中科院分区：
文献类型：
--
作者：
J. Castle;P. Arvan;R. Cameron
外分泌腺的腺泡细胞高度专一地产生、储存和释放分泌蛋白，用于代表生物体和周围环境之间的界面的表面。这些功能是通过分泌途径实现的，分泌途径包括一系列功能不同的细胞内隔室-内质网、GO/GI复合体的亚隔室，以及高浓度储存可输出大分子的分泌颗粒。大多数分泌物是通过颗粒胞吐反应外界激素或神经刺激而发生的。虽然这些过程已经在各种形态和生化研究中被追踪，但关于促进和维持分泌存储、协调顶端细胞表面的放电以及确保颗粒膜的保存和再内化的机制知之甚少。最近从大鼠腮腺获得的细胞组分的研究为了解颗粒内部普遍存在的蛋白质储存条件和颗粒膜可能参与一般分泌功能(如胞吐作用)的成分提供了重要的见解。
Acinar cells of exocrine glands are highly specialized for producing, storing, and discharging secretory proteins for use on surfaces that represent interfaces between the organism and the surrounding environment. These functions are achieved through the secretory pathway that includes a series of functionally distinct intracellular compartments — The endoplasmic reticulum, subcompartmenls of the Go/gi complex, and the secretion granule in which exportable macromolecules are stored at high concentrations. Most secretion occurs by granule exocytosis in response to external hormonal or neural stimuli. Although these processes have been traced in a variety of morphological and biochemical studies, very little is known about the mechanisms involved in facilitating and maintaining secretory storage, orchestrating discharge at the apical cell surface, and in ensuring conservation and re-internalization of the granule membrane. Recent studies initiated on cell fractions obtained from the rat parotid gland have provided significant insight into the protein storage conditions that prevail in the granule interior and the components of the granule membrane that are likely to be involved in general secretory function such as exocytosis.
人红细胞血影蛋白的结构模型。
DOI：
--
发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Speicher,DW;Morrow,JS;Knowles,WJ;Marchesi,VT
通讯作者：
Marchesi,VT
大鼠腮腺分泌颗粒中L-抗坏血酸的鉴定。
DOI：
--
发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
vonZastrow,M;Tritton,TR;Castle,JD
通讯作者：
Castle,JD
在外分泌胰腺中，非糖基化分泌蛋白从粗面内质网的退出是异步的。
DOI：
--
发表时间：
1985
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Scheele,G;Tartakoff,A
通讯作者：
Tartakoff,A