The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors
The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors
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DOI：
10.4049/jimmunol.171.5.2326
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发表时间：
2003-09-01
影响因子：
4.4
通讯作者：
Allman, D
中科院分区：
文献类型：
--
作者：
Miller, JP;Allman, D
B细胞前体细胞的初级年龄相关丢失被认为是在亲B细胞向前B细胞转变的时候。然而，我们发现，在老年C57BL/6小鼠中，所有B细胞谱系的祖细胞群体的频率和绝对数量都下降了，包括致力于B谱系的前B细胞和多潜能的B淋巴祖细胞。此外，当来自老龄小鼠时，每个受检人群中的淋巴祖细胞表现出次优的IL-7反应，表明与年龄相关的次优IL-7R信号是所有早期B系前体的共同特征。总而言之，这些数据表明，在B细胞发育的最早阶段，衰老会导致以前未被意识到的衰退。
The primary age-related loss in B cell progenitors is thought to be at the pro- to pre-B cell transition. However, we show that the frequencies and absolute numbers of all progenitor populations for the B cell lineage, including B-lineage-committed pro-B cells and multipotent B-lymphoid progenitors, decline in aged C57BL/6 mice. Moreover, when derived from aged mice, lymphoid progenitors within every population examined exhibited suboptimal IL-7 responsiveness, demonstrating that age-associated suboptimal IL-7R signaling is a general property of all early B-lineage precursors. Collectively, these data indicate that aging results in a previously unappreciated decline in the earliest stages of B cell development.