Mathematical Modeling and Scale-up of Liquid Chromatography
Mathematical Modeling and Scale-up of Liquid Chromatography
复制标题
液相色谱的数学建模和放大
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
T. Gu
中科院分区：
文献类型：
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作者：
T. Gu
液相色谱已被证明是最重要的分离工具之一。生物技术的快速发展增加了分析、制备和大规模应用中对色谱的需求。了解色谱动力学对于扩大规模至关重要。本书系统地介绍了各种形式的液相色谱的一般速率模型，包括吸附、尺寸排阻、亲和力、反相、疏水相互作用和径向流色谱。讨论了液相色谱中的热力学和传质效应。描述了速率模型的计算机程序的应用，并给出了使用通用速率模型放大制备型和大规模液相色谱的程序。
Liquid chromatography has proved to be one of the most important tools for separations. Rapid development in biotechnology has increased the demand for chromatography in analytical, preparative and large-scale applications. The understanding of the dynamics of chromatography is imperative for the scale-up. This book is a systematic treatment of the general rate models for various forms of liquid chromatography including adsorption, size exclusion, affinity, reversed phase, hydrophobic interaction, and radial flow chromatography. Thermodynamic and mass transfer effects in liquid chromatography are discussed. Applications of computer programs for the rate models are described and the procedures for the scale-up of preparative- and large-scale liquid chromatography using the general rate models are given.