DELAYED DEGENERATION OF THE OPTIC TRACT AND NEURONS IN THE SUPERIOR COLLICULUS AFTER FOREBRAIN ISCHEMIA
DELAYED DEGENERATION OF THE OPTIC TRACT AND NEURONS IN THE SUPERIOR COLLICULUS AFTER FOREBRAIN ISCHEMIA
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DOI：
10.1016/0304-3940(92)90744-r
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发表时间：
1992-09-14
影响因子：
2.5
通讯作者：
BUZSAKI, G
中科院分区：
文献类型：
--
作者：
GALLYAS, F;HSU, M;BUZSAKI, G
观察成年大鼠首次缺血后1 ~ 5天（短期组）和1 ~ 5个月（长期组）15 min前脑缺血对神经元的损伤。除了先前报道的易感区域外，我们观察到视神经束也非常易感。视束变性和随后的上丘跨突触细胞死亡进展缓慢，仅在长期组中观察到。这种感觉系统的延迟、进行性神经元损伤可以作为研究损伤脑长期变化机制的合适模型。
Neuronal damage induced by 15-min forebrain ischemia was investigated in adult rats 1-5 days (short-term group) and 1-5 months (long-term group) after the initial ischemic attack. In addition to the vulnerable areas reported previously, we observed that the optic tract was also very susceptible. Degeneration of the optic tract and subsequent transsynaptic cell death in the superior colliculus developed slowly and was observed only in the long-term group. The delayed, progressive neuronal damage in this sensory system may serve as a suitable model to investigate the mechanisms of long-term changes in the injured brain.