Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4).
Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4).
复制标题
代谢型谷氨酸受体 4 (mGluR4) 的新型正变构调节剂 (PAM) 的合成和 SAR。
DOI：
10.1016/j.bmcl.2009.07.072
复制
发表时间：
2009
影响因子：
2.7
通讯作者：
Hopkins,CoreyR
中科院分区：
文献类型：
--
作者：
Williams,Richard;Johnson,KariA;Gentry,PatrickR;Niswender,ColleenM;Weaver,CharlesD;Conn,PJeffrey;Lindsley,CraigW;Hopkins,CoreyR
这封信描述了合成和SAR的新的积极变构调节剂，VU0155041，一种化合物，已显示在体内的疗效在啮齿动物模型的帕金森氏病。该合成利用迭代并行合成方法来快速合成和评估VU0155041的许多类似物。
This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson’s disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041.