Correlation between neurotrophic factor expression and outcome of children with severe traumatic brain injury
Correlation between neurotrophic factor expression and outcome of children with severe traumatic brain injury
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DOI：
10.1007/s00134-003-1852-6
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发表时间：
2003-08-01
影响因子：
38.9
通讯作者：
Aloe, L
中科院分区：
文献类型：
--
作者：
Chiaretti, A;Piastra, M;Aloe, L
Objectives: We evaluated the neurotrophic factors [nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glia-derived neurotrophic factor (GDNF)] expression and their association with the severity and outcome of children with traumatic brain injury. Design: Prospective observational clinical study. Setting: Pediatric intensive care unit. Patients: Fourteen children with severe head injury; 12 controls with obstructive hydrocephalus. Measurement: Cerebrospinal fluid (CSF) and plasma samples were collected 2 h (T1) and 24 h (T2) after head injury. Neurotrophic factor levels were measured using an immunoenzymatic assay. Main results: In patients, neurotrophic factor mean levels were significantly different in both CSF and plasma, showing high levels of BDNF compared to NGF and GDNF. Considering T1 and T2 expression, in the CSF the level of NGF increased from 3.5 +/- 0.4 pg/ml to 48.2 +/- 11.7 pg/ml (p
