Filarial infection influences mosquito behaviour and fecundity
Filarial infection influences mosquito behaviour and fecundity
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DOI：
10.1038/srep36319
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发表时间：
2016-10-31
影响因子：
4.6
通讯作者：
Reimer, Lisa J.
中科院分区：
文献类型：
--
作者：
Gleave, Katherine;Cook, Darren;Reimer, Lisa J.
随着我们向消除淋巴丝虫病全球方案（GPELF）设定的终点目标迈进，了解病媒-寄生虫相互作用越来越重要，因为相互作用动态可能会随着传播压力的降低而改变。消除模型用于预测程序性终点包括特定媒介的传播动力学参数，尽管事实上，我们的知识丝虫病感染的蚊子的宿主寻找行为是缺乏的。我们观察到一个动态的，阶段特异性和密度依赖性的变化，埃及伊蚊的行为对主机线索时，暴露于马来丝虫丝虫寄生虫。感染的蚊子在幼虫发育期间（L1/L2）表现出减少的激活和向宿主的飞行，当存在感染期幼虫（L3）时，向宿主的激活和飞行转变为5倍增加（p < 0.001）。在未感染的对照蚊子中，我们观察到在同一时期向宿主收敛的减少。此外，这种行为是密度依赖性的，未活化的蚊子携带更多的L1和L2幼虫，而活化的蚊子携带更多数量的L3（p < 0.001）。繁殖力的降低也是密度依赖性的，并延伸到暴露于微丝蚴但不支持幼虫发育的蚊子。
Understanding vector-parasite interactions is increasingly important as we move towards the endpoint goals set by the Global Programme for the Elimination of Lymphatic Filariasis (GPELF), as interaction dynamics may change with reduced transmission pressure. Elimination models used to predict programmatic endpoints include parameters for vector-specific transmission dynamics, despite the fact that our knowledge of the host-seeking behaviour of filariasis infected mosquitoes is lacking. We observed a dynamic, stage-specific and density dependent change in Aedes aegypti behaviour towards host cues when exposed to Brugia malayi filarial parasites. Infected mosquitoes exhibited reduced activation and flight towards a host during the period of larval development (L1/L2), transitioning to a 5 fold increase in activation and flight towards a host when infective stage larvae (L3) were present (p < 0.001). In uninfected control mosquitoes, we observed a reduction in convergence towards a host during the same period. Furthermore, this behaviour was density dependent with non-activated mosquitoes harbouring a greater burden of L1 and L2 larvae while activated mosquitoes harboured a greater number of L3 (p < 0.001). Reductions in fecundity were also density-dependent, and extended to mosquitoes that were exposed to microfilariae but did not support larval development.