Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease
Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease
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DOI：
10.1523/jneurosci.21-03-01033.2001
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发表时间：
2001-02-01
影响因子：
5.3
通讯作者：
Di Lazzaro, V
中科院分区：
文献类型：
--
作者：
Brown, P;Oliviero, A;Di Lazzaro, V
帕金森病中基底神经节核内部和核之间的同步程度尚不清楚。这个问题很重要，因为同步将提高后续投射目标的突触后功效。我们同时记录了四名帕金森病神经外科手术后清醒患者的苍白球内层 (GPi) 和丘脑底核 (STN) 的局部电位 (LP)。两名患者的两侧细胞核均被记录，因此总共进行了六次同侧 GPi-STN LP 记录。在没有药物治疗的情况下，GPi 和 STN 内部的功率和一致性由具有一定频率的活动主导
The extent of synchronization within and between the nuclei of the basal ganglia is unknown in Parkinson's disease. The question is an important one because synchronization will increase postsynaptic efficacy at subsequent projection targets. We simultaneously recorded local potentials (LPs) from the globus pallidus interna (GPi) and subthalamic nucleus (STN) in four awake patients after neurosurgery for Parkinson's disease. Nuclei from both sides were recorded in two patients so that a total of six ipsilateral GPi-STN LP recordings were made. Without medication, the power within and the coherence between the GPi and STN was dominated by activity with a frequency