Relationship between the C5 peptides chemotactic for leukocytes and tumor cells.
Relationship between the C5 peptides chemotactic for leukocytes and tumor cells.
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C5肽对白细胞和肿瘤细胞趋化的关系。
DOI：
10.4049/jimmunol.117.5_part_2.1762
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发表时间：
1976
影响因子：
4.4
通讯作者：
T. Torikata
中科院分区：
文献类型：
--
作者：
A. Romualdez;P. Ward;T. Torikata
已经证明了从C5产生的白细胞趋化肽和肿瘤细胞趋化肽之间的相互关系。胰蛋白酶产生的C5趋白细胞肽可以通过用肿瘤细胞提取物处理或通过与从人血清分离的α-球蛋白趋化因子灭活剂（CFI）孵育而转化为肿瘤细胞趋化因子。从大鼠血清中分离的类似CFI可以像从人血清中分离的α-球蛋白CFI一样，从整个人血清中产生肿瘤细胞趋化因子。这些结果表明，肿瘤细胞趋化因子来源于C5分子的相同部分作为白细胞趋化肽。此外，似乎关键的变化可能是裂解的氨基末端部分的白细胞趋化肽。此外，已经表明，大多数正常组织含有能够在正常人血清中产生肿瘤细胞趋化因子的酶样物质。这些研究结果的影响进行了讨论。
A reciprocal relationship has been demonstrated between the generation of the leukotactic and the tumor cell chemotactic peptides from C5. Trypsin-produced C5 leukotactic peptides can be converted into tumor cell chemotactic factors by treatment with tumor cell extracts or by incubation with the alpha-globulin chemotactic factor inactivator (CFI) isolated from human serum. A similar CFI isolated from rat serum can, like the alpha-globulin CFI from human serum, generate the tumor cell chemotactic factor from the whole human serum. These results suggest that the tumor cell chemotactic factor derives from the same portion of the C5 molecule as the leukotactic peptide. Furthermore, it appears that the critical change may be cleavage of the amino-terminal portion of the leukotactic peptide. In addition, it has been shown that most normal tissues contain an enzyme-like material that is able to generate in normal human serum a factor chemotactic for tumor cells. The implications of these findings are discussed.