6'-O-Galloylpaeoniflorin attenuates Helicobacter pylori-associated gastritis via modulating Nrf2 pathway
6'-O-Galloylpaeoniflorin attenuates Helicobacter pylori-associated gastritis via modulating Nrf2 pathway
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DOI：
10.1016/j.intimp.2022.109122
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发表时间：
2022
影响因子：
5.6
通讯作者：
Chaojun Zhang
中科院分区：
文献类型：
--
作者：
Yun Zhang;Maihuan Wang;Kebin Zhang;Junze Zhang;Xinpu Yuan;Guijun Zou;Zhen Cao;Chaojun Zhang
As a common disease of the digestive system, chronic gastritis is inflammation of the gastric mucosa caused by .various factors. Helicobacter pylori (H. pylori) is one of the main causes of chronic gastritis, which can lead to .gastric mucosal damage and gland atrophy, thereby promoting gastrocarcinogenesis. Oxidative stress and the .inflammatory response are important mechanisms of H. pylori-induced gastritis. 6′.-O-Galloylpaeoniflorin (GPF) is .a substance isolated from peony root with antioxidant and anti-inflammatory activities. However, its role and .mechanism in the pathogenesis of H. pylori-induced chronic gastritis remain unclear. This study explored the .effects of GPF on H. pylori-induced gastric mucosal oxidative stress and inflammation using flow cytometry, .western blotting, real-time quantitative PCR, and immunohistochemistry. We found that H. pylori infection .increased oxidative stress and expression of inflammatory cytokines in vitro and in vivo and that these outcomes .were inhibited by GPF. Furthermore, GPF activated nuclear factor erythroid-related factor-2 (Nrf2) and its .downstream target genes in H. pylori-infected GES-1 cells and mice. The anti-inflammatory and antioxidant effects of GPF on H. pylori-infected cells were attenuated by an Nrf2 inhibitor. Taken together, these data suggest .that GPF reduces H. pylori-induced gastric mucosa injury by activating Nrf2 signaling and that GPF is a potential .candidate for the treatment of H. pylori-associated gastritis.
