Impairment of skilled forelimb use after ablation of striatal interneurons expressing substance P receptors in rats: an analysis using a pasta matrix reaching task
Impairment of skilled forelimb use after ablation of striatal interneurons expressing substance P receptors in rats: an analysis using a pasta matrix reaching task
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DOI：
10.1007/s00221-004-2189-2
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发表时间：
2005-05-01
影响因子：
2
通讯作者：
Tokuno, H
中科院分区：
文献类型：
--
作者：
Chiken, S;Tokuno, H
局部注射P物质皂苷可引起表达SP受体（SPR）的纹状体中间神经元选择性消融。在这项研究中，我们使用面食基质到达任务定量评估了大鼠单侧纹状体中间神经元消融后熟练前肢使用的损伤。我们发现，使用消融对侧实验侧爪取到的意大利面（未煮熟的意大利面）数量显著减少，而使用完整侧爪取到的意大利面数量显著增加。这些发现与我们之前的报道一致，表明纹状体中间神经元对皮质-纹状体-针束内直接通路的调节对于维持正常的基底神经节对熟练的前肢运动的控制是重要的。
Local injection of substance P (SP)-saporin can cause selective ablation of striatal interneurons expressing SP receptors (SPR). In this study, we evaluated quantitatively the impairment of skilled forelimb use after unilateral ablation of the striatal interneurons using a pasta matrix reaching task in rats. We found a significant decrease of the number of the pasta pieces (uncooked spaghetti) retrieved using the paw of the experimental side contralateral to the ablation, whereas the number of the pasta pieces retrieved using the paw of the intact side increased significantly. These findings, with our previous reports, suggest that the modulation of the cortico-striato-entopeduncular direct pathway by striatal interneurons is important for maintaining normal basal-ganglia control for skilled forelimb movements.