Laminin-5 gamma 2 chain and matrix metalloproteinase-2 may trigger colorectal carcinoma invasiveness through formation of budding tumor cells.
Laminin-5 gamma 2 chain and matrix metalloproteinase-2 may trigger colorectal carcinoma invasiveness through formation of budding tumor cells.
复制标题
Laminin-5 γ 2 链和基质金属蛋白酶-2 可能通过形成出芽肿瘤细胞来触发结直肠癌的侵袭性。
作者：
T. Masaki;H. Matsuoka;M. Sugiyama;N. Abe;Y. Izumisato;A. Goto;A. Sakamoto;Y. Atomi
未标记的
UNLABELLED
Tumor budding has been reported to be significantly associated with lymph node or distant metastasis in colorectal carcinomas. We attempted to elucidate the contributing factors for the formation of budding tumor cells.
PATIENTS AND METHODS
Fifty T1 colorectal carcinomas were immunostained using several antibodies against adhesion-related molecules, and the associations between tumor budding and clinicopathological factors were examined.
RESULTS
Univariate analysis revealed that predominant histology, lymphatic permeation, depth of invasion, width of invasion, CD44 variant 6 expression, laminin-5 gamma 2 chain expression and stromal MMP-2 expression were associated with tumor budding. Multivariate analysis showed that lymphatic permeation, laminin-5 gamma 2 chain expression and stromal MMP-2 expression were independently and significantly associated with tumor budding. Furthermore, laminin-5 gamma 2 chain and stromal MMP-2 expression patterns were significantly associated with locoregional failure.
CONCLUSION
These results suggest that laminin-5 gamma 2 chain and MMP-2 may contribute synergistically to the formation of budding tumor cells.