Mesenchymal tumors of the uterus: III. A clinical and pathologic study of 31 carcinosarcomas
Mesenchymal tumors of the uterus: III. A clinical and pathologic study of 31 carcinosarcomas
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子宫间叶质肿瘤：III。
DOI：
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发表时间：
1966
期刊：
影响因子：
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通讯作者：
H. Taylor
中科院分区：
文献类型：
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作者：
H. Norris;H. Taylor
本文介绍了 31 例子宫癌肉瘤患者的临床和病理结果。癌肉瘤发生在子宫内膜内，除 2 例外，所有癌肉瘤均侵入子宫肌层和淋巴管。在初始治疗时，12 名患者 (39%) 的肿瘤已扩散到子宫以外。最后一次接触时未发现癌症的 8 名患者 (26%) 中没有一人出现子宫外扩展或转移。由于癌肉瘤患者的生存率明显高于类似的混合性中胚层肿瘤患者，因此应将两种类型的肿瘤分开。作者认为，癌肉瘤既源自具有形成上皮和间质能力的多能肿瘤细胞，又源自具有固定潜能的多种肿瘤细胞类型。来自胚胎静止、原始生长蛋白或碰撞肿瘤的起源被拒绝。由于子宫癌肉瘤的转移病灶分布与子宫内膜癌相似，因此手术治疗也应相似。目前尚不清楚放射治疗是否具有任何治疗价值。
The clinical and pathologic findings of 31 patients with uterine carcinosarcoma are presented. Carcinosarcomas arose within the endometrium and all but 2 invaded the myometrium and lymphatic spaces. Tumor had spread beyond the uterus in 12 (39%) of patients at the time of initial therapy. None of 8 patients (26%) who were free of cancer at last contact had extra‐uterine extension or metastasis. Because the patients with carcinosarcoma had a significantly better survival rate than did a similar group with mixed mesodermal tumors, the 2 types of neoplasms should be separated. The authors believe that carcinosarcomas arise both from multipotent neoplastic cells that have the capacity to form both epithelium and stroma and from multiple neoplastic cell types having fixed potencies. Origin from embryonal rests, primitive analagen, or collision tumors is rejected. Because the distribution of metastatic lesions of uterine carcinosarcomas is similar to that of endometrial carcinomas, surgical management should be similar. It is not clear whether irradiation has any value as treatment.