Association of skin with the pathogenesis and treatment of neurodegenerative amyloidosis.
Association of skin with the pathogenesis and treatment of neurodegenerative amyloidosis.
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DOI：
10.3389/fneur.2012.00005
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发表时间：
2012
影响因子：
3.4
通讯作者：
Lasagna-Reeves CA
中科院分区：
文献类型：
--
作者：
Clos AL;Kayed R;Lasagna-Reeves CA
淀粉样变性是一大类构象疾病，其特征是蛋白质折叠和组装异常，导致不溶性蛋白质聚集体的积累，这些聚集体可能在某些器官或组织中全身或局部积累。在局部淀粉样变性中，淀粉样蛋白沉积仅限于特定器官或组织。阿尔茨海默病、帕金森病和肌萎缩侧索硬化症是神经退行性淀粉样变性的一些例子。皮肤中蛋白质聚集的局部表现也有报道。大脑和皮肤在生理和病理层面上高度相连。最近的几项研究表明，在不同的淀粉样蛋白疾病中，大脑和皮肤之间存在密切的联系。在本综述中，我们讨论了“脑-皮肤连接”在不同神经退行性淀粉样变性中的相关性，不仅在病理水平上，而且作为治疗这些疾病的策略。
Amyloidosis are a large group of conformational diseases characterized by abnormal protein folding and assembly which results in the accumulation of insoluble protein aggregates that may accumulate systemically or locally in certain organs or tissue. In local amyloidosis, amyloid deposits are restricted to a particular organ or tissue. Alzheimer’s, Parkinson’s disease, and amyotrophic lateral sclerosis are some examples of neurodegenerative amyloidosis. Local manifestation of protein aggregation in the skin has also been reported. Brain and skin are highly connected at a physiological and pathological level. Recently several studies demonstrated a strong connection between brain and skin in different amyloid diseases. In the present review, we discuss the relevance of the “brain–skin connection” in different neurodegenerative amyloidosis, not only at the pathological level, but also as a strategy for the treatment of these diseases.