Small matters: Introduction to extracellular vesicles.
Small matters: Introduction to extracellular vesicles.
复制标题
小事：细胞外囊泡简介。
DOI：
10.1111/imr.13140
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发表时间：
2022
影响因子：
8.7
通讯作者：
Boulanger,ChantalM
中科院分区：
文献类型：
--
作者：
Ley,Klaus;Boulanger,ChantalM
这期《免疫学评论》专刊专门介绍细胞外囊泡（EV），它包括微囊泡（也称为微粒）、外泌体、外泌体和细长的嗜中性粒细胞衍生结构（ENDS）。六个领先的研究小组在六篇评论中提供了他们的观点，提供了不同的观点，意见和重点领域。EV领域目前已经成熟，从基础研究领域转向诊断和治疗目的的转化。西班牙巴塞罗那圣保罗的Lina Badimon和她的团队专注于EV作为动脉粥样硬化性心血管疾病（ASCVD）的预后，诊断和预测标志物的前景。ASCVD的急性事件由动脉粥样硬化血栓形成触发，其中EV在动脉粥样硬化的发生、进展和并发症中起重要作用。电动汽车来自所有的细胞。有些已被证明是预测性的，其他预后，和一些诊断的显性疾病。也许最好理解的是血小板衍生的EV，其明显是促血栓形成的，但EV也可以参与新血管形成和血管生成，这表明了治疗潜力。1
This special issue of Immunological Reviews is devoted to extracellular vesicles (EVs), which comprise microvesicles (also known as microparticles), exosomes, ectosomes, and elongated neutrophilderived structures (ENDS). Six leading research groups provide their perspective in six reviews, providing different perspectives, opinions, and areas of focus. The EV field is now mature, moving from the realm of basic research into translation for diagnostic and therapeutic purposes.Lina Badimon of San Pau, Barcelona, Spain, and her group focus on the promise that EVs hold as prognostic, diagnostic, and predictive markers of atherosclerotic cardiovascular disease (ASCVD). Acute events from ASCVD are triggered by arterial atherothrombosis, in which EVs play important roles in the initiation, progression, and complications of atherosclerosis. EVs come from all cells. Some have been shown to be predictive, others prognostic, and some diagnostic of manifest disease. Perhaps best understood are plateletderived EVs, which are clearly prothrombotic, but EVs can also be involved in neovascularization and angiogenesis, suggesting therapeutic potential. 1