Common mental disorders within chronic inflammatory disorders: a primary care database prospective investigation
Common mental disorders within chronic inflammatory disorders: a primary care database prospective investigation
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DOI：
10.1136/annrheumdis-2018-214676
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发表时间：
2019-05-01
影响因子：
27.4
通讯作者：
Hotopf, Matthew
中科院分区：
文献类型：
--
作者：
Dregan, Alexandru;Matcham, Faith;Hotopf, Matthew
目的在基层医疗环境中，关于炎症性疾病与抑郁和焦虑发作之间的关联性，存在不一致的证据。该研究旨在评估多系统和器官特异性炎症disorders.Methods内抑郁和焦虑的风险，这是一项前瞻性队列研究，从英国临床实践研究Datalink诊断为炎症性疾病的初级保健患者2001年1月1日至2016年12月31日。这些患者在年龄、性别、实践和索引日期上与没有炎症性疾病的患者相匹配。研究暴露为7种慢性炎症性疾病。抑郁症和焦虑症的临床诊断结果的interests.Results措施，在538 707名参与者中，抑郁症的发病率范围从14每1000人年（严重银屑病）9每1000人年（系统性血管炎），实质上高于他们的对照组（5 - 7每1000人年）。炎症性疾病中多重抑郁和焦虑事件的HR高16%（HR，1.16，95%CI 1.12 - 1.21，p
Objective There is inconsistent evidence about the association between inflammatory disorders and depression and anxiety onset in a primary care context. The study aimed to evaluate the risk of depression and anxiety within multisystem and organ-specific inflammatory disorders.Methods This is a prospective cohort study with primary care patients from the UK Clinical Practice Research Datalink diagnosed with an inflammatory disorder between 1 January 2001 and 31 December 2016. These patients were matched on age, gender, practice and index date with patients without an inflammatory disorder. The study exposures were seven chronic inflammatory disorders. Clinical diagnosis of depression and anxiety represented the outcome measures of interest.Results Among 538 707 participants, the incidence of depression ranged from 14 per 1000 person-years (severe psoriasis) to 9 per 1000 person-years (systemic vasculitis), substantively higher compared with their comparison group (5-7 per 1000 person-years). HRs of multiple depression and anxiety events were 16% higher within inflammatory disorders (HR, 1.16, 95% CI 1.12 to 1.21, p