p21 expression is a prognostic factor in patients with p53-negative gastric cancer
p21 expression is a prognostic factor in patients with p53-negative gastric cancer
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DOI：
10.1016/s0304-3835(99)00335-3
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发表时间：
2000-02-01
期刊：
影响因子：
9.7
通讯作者：
Aikou, T
中科院分区：
文献类型：
--
作者：
Che, XM;Hokita, S;Aikou, T
采用免疫组织化学方法分析 256 例晚期胃癌患者中 p21 和 p53 蛋白的表达。结果显示，p21强表达、弱表达和阴性表达的患者分别为22.2%（57/256）、68.0%（174/256）和9.8%（25/256）。 p53 表达率为 28.9% (74/256)。 p21的表达与临床病理特征无关。在 p53 阴性肿瘤中，p21 表达与接受根治性手术的患者的生存率相关（P = 0.007）。 p21阴性、弱阳性和强阳性肿瘤患者的5年生存率分别为20.1%、36.6%和59.8%。相比之下，在 p53 阳性肿瘤中，尽管 p21 表达，但预后没有差异。多变量分析显示p21表达是p53阴性肿瘤患者的独立因素。这些结果表明p53阴性肿瘤中p21表达的检查将有助于估计晚期胃癌患者的预后。 (C) 2000 Elsevier Science Ireland Ltd. 保留所有权利。
The expression of p21 and p53 proteins was analyzed by immunohistochemistry in 256 patients with advanced gastric cancer. The results showed that strong, weak and negative expression of p21 were detected in 22.2 (57/256), 68.0 (174/256) and 9.8% (25/256) of the patients, respectively. p53 expression was found in 28.9% (74/256). The expression of p21 was not associated with clinicopathological features. In p53 negative tumors, p21 expression was associated with the survival of patients who underwent curative operations (P = 0.007). The 5-year survival rates were 20.1, 36.6 and 59.8% in patients with p21-negative, weakly positive and -strongly positive tumors, respectively. In contrast, in p53-positive tumors, prognosis did not differ in spite of p21 expression. Multivariate analysis showed that p21 expression was an independent factor in patients with p53-negative tumors. These results indicate that examination of p21 expression in p53 negative tumors will be useful for estimating the prognosis of patients with advanced gastric cancer. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.