Genetic predisposition to anxiety-related behavior determines coping style, neuroendocrine responses, and neuronal activation during social defeat
Genetic predisposition to anxiety-related behavior determines coping style, neuroendocrine responses, and neuronal activation during social defeat
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DOI：
10.1037/0735-7044.120.1.60
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发表时间：
2006-02-01
影响因子：
1.9
通讯作者：
Wigger, A
中科院分区：
文献类型：
--
作者：
Frank, E;Salchner, P;Wigger, A
遗传背景可能会影响一个人的易感性，以及随后的应对策略，急性应激。当暴露于社会失败（SD），大鼠饲养的高（HAB）或低（LAB）特质焦虑，这也不同的抑郁样行为，表现出高度不同的被动和主动的应对行为，分别。HAB花更多的时间冻结和发出更多的超声波发声呼叫在SD比LAB，花更多的时间饲养和梳理。虽然行为数据证实的预测，提高特质焦虑会使大鼠更容易经历压力，促肾上腺皮质激素和皮质酮分泌的程度较高，在LAB比在HAB。在后者中，Fos的表达后SD增强杏仁核和下丘脑区与LAB相比，而减少在前额叶和脑干区。
Genetic background may influence an individual's susceptibility to, and subsequent coping strategy for, an acute stressor. When exposed to social defeat (SD), rats bred for high (HAB) or low (LAB) trait anxiety, which also differ in depression-like behavior, showed highly divergent passive and active coping behaviors, respectively. HABs spent more time freezing and emitted more ultrasound vocalization calls during SD than LABs, which spent more time rearing and grooming. Although the behavioral data confirmed the prediction that heightened trait anxiety would make rats more prone to experience stress, adrenocorticotropin and corticosterone were secreted to a higher extent in LABs than in HABs. In the latter, Fos expression upon SD was enhanced in the amygdala and hypothalamic areas compared with LABs, whereas it was diminished in prefrontal and brainstem areas.