Comprehensive analysis about prognostic and immunological role of WTAP in pan-cancer.
Comprehensive analysis about prognostic and immunological role of WTAP in pan-cancer.
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DOI：
10.3389/fgene.2022.1007696
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发表时间：
2022
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
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背景：Wilms Tumor 1相关蛋白(WTAP)在N6腺苷(M6A)修饰的核糖核酸(RNA)甲基化中起关键作用，与多种生物学过程密切相关。然而，WTAP在癌症中的作用仍有待确定。本研究旨在展示WTAP在泛癌中的预后图景，并探讨WTAP表达与免疫浸润的关系。方法：在这里，我们使用多个数据库，包括PrognoScan、GEPIA和Kaplan-Meier绘图仪，研究WTAP在泛癌中的表达水平和预后作用。然后，应用GEPIA和TIMER数据库，我们阐明了WTAP在肿瘤中的表达与免疫浸润的相关性，特别是肝细胞癌(LIHC)和食道癌(ESCA)。结果：WTAP在ESCA、LIHC等肿瘤组织中高表达，在膀胱尿路上皮癌(BLCA)、乳腺浸润癌(BRCA)等肿瘤组织中低表达，WTAP对肿瘤的预后有多方面的预测价值。我们感兴趣的是，WTAP对LIHC患者的总生存期(OS)和无进展生存期(PFS)产生了不利影响。WTAP的表达与B细胞、CD8+T细胞、CD4+T细胞、巨噬细胞、中性粒细胞和树突状细胞(DC)在LIHC中的浸润程度显著相关，而与ESCA的浸润程度无关。此外，WTAP表达水平和免疫细胞特异性基因标志物的联合分析表明，WTAP与LIHC和ESCA中调节细胞(T Reg)的渗透有关。结论：在泛癌中，m6A调节因子WTAP可以作为某些肿瘤类型的预后生物标志物，并且可能是免疫细胞渗透的结果。
Background: Wilms tumor 1-associated protein (WTAP) plays a critical role in ribonucleic acid (RNA) methylation of N6 adenosine (m6A) modification, which is closely related with varieties of biological process. However, the role of WTAP in cancers remains to be determined. This study is designed to demonstrate the prognostic landscape of WTAP in pan-cancer and explore the relationship between WTAP expression and immune infiltration. Methods: Here, we investigated the expression level and prognostic role of WTAP in pan-cancer using multiple databases, including PrognoScan, GEPIA, and Kaplan-Meier Plotter. Then, applying the GEPIA and TIMER databases, we illustrated the correlations between WTAP expression and immune infiltration in tumors, especially liver hepatocellular carcinoma (LIHC), and esophageal carcinoma (ESCA). Results: WTAP had significant higher expression levels in tumor tissues of ESCA, LIHC, etc., while lower expression levels in those of bladder urothelial carcinoma (BLCA), breast invasive carcinoma (BRCA), etc. And WTAP demonstrated multifaceted prognostic value in cancers. Of our interests, WTAP exerted a harmful effect on LIHC patient for overall survival (OS) and progression free survival (PFS). WTAP expression also significantly associated with the infiltration levels of B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells (DC) in LIHC but not ESCA. Furthermore, combined analysis about WTAP expression level and immune cell specific gene markers implied WTAP correlates with regulatory cells (T reg) infiltration in LIHC and ESCA. Conclusion: The m6A regulator WTAP can serve as a prognostic biomarker for certain tumor types in pan-cancer and potentially result from immune cell infiltration.
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