Sensory gating deficits in schizophrenia: new results.
Sensory gating deficits in schizophrenia: new results.
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DOI：
10.1176/ajp.149.4.488
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发表时间：
1992-04
期刊：
影响因子：
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通讯作者：
L. Judd;L. Mcadams;Byron Budnick;D. Braff
中科院分区：
文献类型：
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作者：
L. Judd;L. Mcadams;Byron Budnick;D. Braff
目的 人们普遍假设，与正常人相比，精神分裂症患者会出现感觉门控故障和感觉超负荷。这项研究的作者试图证实和扩展早期研究的结果，这些研究显示精神分裂症患者存在特定的感觉门控缺陷。方法 使用电生理记录的 P50 事件相关电位对年龄和性别匹配的精神分裂症患者 (N = 20) 和正常受试者 (N = 20) 进行测试，通过测量感觉过滤或门控来评估受试者中枢感觉抑制能力的整体能力。记录每个受试者对两次持续时间为 0.04 毫秒的 75 分贝（调节和测试）点击刺激的 P50 面积响应，平均超过 60 次试验。通常，第一次（调节）点击刺激会诱导门控机制，导致响应第二次点击刺激而减少或门控 P50 事件相关电位。结果精神分裂症受试者在额叶、中央和顶叶电极放置部位表现出显着的感觉门控缺陷，但这种缺陷在大脑额叶区域最为突出的趋势不显着。结论 这些数据反映了精神分裂症患者正常感觉门控的区域性弥漫性丧失。
OBJECTIVE It has been widely hypothesized that sensory gating failures and sensory overload occur in schizophrenic patients compared to normal subjects. The authors of this study sought to confirm and extend results of earlier studies that showed specific sensory gating deficits in schizophrenic patients. METHOD Age- and sex-matched schizophrenic patients (N = 20) and normal subjects (N = 20) were tested using electrophysiologically recorded P50 event-related potentials to assess the overall competence of the subjects' central sensory inhibitory capacity by measuring sensory filtering or gating. P50 area responses to two 75-dB (conditioning and test) click stimuli of 0.04-msec duration, averaged over 60 trials, were recorded for each subject. Normally, the first (conditioning) click stimulus induces gating mechanisms that result in diminished or gated P50 event-related potentials in response to the second click stimulus. RESULTS The schizophrenic subjects manifested a significant sensory gating deficit at frontal, central, and parietal electrode placement sites, with a nonsignificant tendency for the deficit to be most prominent in the frontal areas of the brain. CONCLUSIONS These data reflect a regionally diffuse loss of normal sensory gating in schizophrenic patients.